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AFP and 40% miss on Downs

From: AC (anonymous@obgyn.net)
Sat, 5 Dec 1998 13:56:27 -0600 (CST)


I was told by a genetic counselor that the AFP will miss 40% of actual Downs cases. My AFP result (taken at 18 weeks) is 1 in 10,000. Does this number take into account the 40% miss rate? I would like to know if I can use 1 in 10,000 as my risk factor or do I need to make adjustments to it.

Thanks.






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