WOMENS-HEALTH Messages for May, 1998: Re: ductal carcinoma in situ and hormone therapy replacement

Re: ductal carcinoma in situ and hormone therapy replacement

From: Robert Radnich, MD (anonymous@obgyn.net)
Thu, 14 May 1998 05:52:08 -0500 (CDT)

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In reply to: Betty: "ductal carcinoma in situ and hormone therapy replacement"
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Betty, Good question. You didn't give your age, but I assume you are postmenopausal since you are already on HRT. There seems to be a relationship between estrogens and breast CA. The most recent studies link this to the dose and time of exposure. I have some women who understand this and desire to continue HRT, but it is a risk. I would not advise you to continue HRT.

Evista is a selective estrogen receptor modulator. It is claimed to prevent bone loss and to help prevent heart disease without stimulating the breast or uterus. Studies suggest that there is a protective effect on the breast - similar to tamoxephene. The studies have not been ongoing for long enough to really have adequate data, but it looks promising at this time.

It is a new drug, and thus has some risk - yet undefined. It also does not help with the symptoms of menopause. All that being said, I would not discourage you from taking Evista. I think it would provide significant protection for your bones and heart - and probably also give you some protection to prevent a recurrance of the breast CA. I wish you well

At Wed, 13 May 1998, Betty wrote: >
>A couple of months ago, I had a breast lump removed. The pathology
>report indicated: "intermediate to high grade ductal carcinoma in situ
>(solid and comedo pattern), extending focally to surgical resection
>margin". The surgeon then did a re-excision to take additional tissue
>from the area and that pathology report indicated: "negative for
>residual ductal carcinoma in situ". I have started radiation
>treatments.
>
>I have been taking hormones (premarin & provera) for several years.
>Should I continue taking those hormones or should I begin taking Evista?
>I have two differing physician opinions.
>
>--
>Betty McFall
>

Next message: Joseph Pastorek, MD: "Re: Ecoli Uterine Infection"
Previous message: Naureen: "Update on message: Should I get my progesterone level checked?"
In reply to: Betty: "ductal carcinoma in situ and hormone therapy replacement"
Next in thread: Barbara: "Re: ductal carcinoma in situ and hormone therapy replacement"

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