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Re: Premarin: estradiol/estrone metabolism

From: Joy (anonymous@obgyn.net)
Fri, 27 Feb 1998 09:32:51 -0600 (CST)


At Mon, 14 Jul 1997, Ronald Barentsen, MD wrote: >gonadism of < 3 mL (the endo of course did not
>>evaluate this persons genitalia, and assessed this individualshealth as
>>'unremarkable').
>>
>>This is all true!! What does this mean???
>>Where did the estradiol come from? Was is from
>>some peripheral conversion of estrone to estradiol?
>>
>>Sincerely ... Melisa
>
>premarin contains about 1% 17-beta estradiol. More important is the
>nearly 50% concentration of oestron in premarin. Oestron is always in
>equilibrium with oestradiol. Where oestron is available, oestradiol can
>be measured. With 1,25 mg premarin a midfolluculair level of oestradiol
>is fonund in most cases. So this is a normal result
>
>--
>Ronald Barentsen
>Correspondent OBGYN.net for menopause and hormone replacement therapy
>





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