WOMENS-HEALTH Messages for December, 1997: Re: tegretol and pregnancy????help!

Re: tegretol and pregnancy????help!

From: Harvey S. Marchbein, M.D. (anonymous@obgyn.net)
Mon, 8 Dec 1997 21:37:41 -0600 (CST)

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In reply to: carisa: "tegretol and pregnancy????help!"

At Mon, 8 Dec 1997, carisa wrote: >
>I am looking for any information I can find for a dear friend on
>tegretol and 10-12 weeks pregnant. She is 24 yrs old and this is her
>3rd child (although her first sice being on tegretol.) She is 3-4 years
>status post brain mass removal and we are trying to find out the risks
>to her baby from the tegretol. ANY info would be great! Is there any
>research done on this?? We turned to the internet as her doctor was
>unable to find anything significant in any books... PLEASE HELP!!

Teratology is the study of abnormalities of development. teratogenicity is the risk or chance of an abnormal development of a fetus or organ system. The literature indicates that the teratogenicity of tegretol is less than 10% and dilatin (another similar use drug) is 10%. The risk to all pregnancies for major birth defects (without relation to genetic exposure) is 3%. The only other article I could find stated the risk of neural tube defects was less than 1%.

I hope this helps. The articles do recommend a minimum of medication, preferably one medication rather than multiples, and that valproic acid (another similar-use medication) may carry a "threefold increase in the risk of neural tube defects as well as an increased risk of other malformations".

-- Harvey S. Marchbein, M.D. FACOG OBGYN.net U.S. Representative, New York Great Neck, N.Y. http://www.obgyn.net/states/bios/marchbein.htm http://www.obgyn.net/women/advisor/harveym.htm

*Note: Opinions expressed here are for educational purposes only. This information is not intended to supplant the need for you to consult your physician prior to choosing or planning therapeutic options and/or interventions.

**Private emails cannot be answered.

**Thank you.

Next message: Harvey S. Marchbein, M.D.: "Re: Egg quality, etc etc Thanks Dr Harvey"
Previous message: Karrie: "Re: No heartbeat heard by doppler at 10 weeks"
In reply to: carisa: "tegretol and pregnancy????help!"

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