WOMENS-HEALTH Messages for November, 1997: Re: over-active thryroid in pregancy

Re: over-active thryroid in pregancy

From: R.Daniel (anonymous@obgyn.net)
Tue, 11 Nov 1997 20:20:48 -0600 (CST)

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In reply to: Patti: "Re: over-active thryroid in pregancy"

At Tue, 11 Nov 1997, Patti wrote: >
>At Sat, 8 Nov 1997, Harvey S. Marchbein, M.D. wrote:
>>
>>At Sat, 8 Nov 1997, Lila wrote:
>>>
>>>My daughter has an over-active thryroid gland and was taking the thryoid
>>>medication for pregnant women, I do not remember the name of the drug.
>>>She suffered a extemely severe drug reaction to this pill and was
>>>hopitalized because she became sick with a sore throat and it was
>>>discovered she had a 0 count of white blood cells. They had to get her
>>>white blood cell count up as she had no immune system. My question is
>>>will this effect the baby. She was about three months pregnant at the
>>>time. She has had an ultra-sound and the baby was fine. Should I be
>>>worried about any other complications due to this drug reaction.
>>
>>The thyroid problem and no white blood cells are seemingly two separate
>>problems. This is too complex for an internet diagnosis. A fetal
>>maternal medicine expert in needed to get a full picture of all the
>>implications.
>>
>I think what Lila may be referring to is a relatively rare side effect
>of taking propylthiouracil or methimazole for
>hyperthyroidism--agranulocytosis. Symptoms include sore throat, fever,
>malaise. I am not a medical doctor, but I know "a bit" about pregnancy
>and hyperthyroidism as I have it. My guess would be that this shouldn't
>affect the baby, it would only affect the mother's ability to fight off
>an infection.
>
>Was your daughter hyperthyroid before she got pregnant? I was not, it
>seems to be pregnancy induced. It was first diagnosed in my second
>pregnancy, went away after I delivered, and now is back with my third.
>This presentation seems pretty rare, so I have hesitated posting any
>questions about it. Any real doctors want to field them?
>
>--
>Patti, Georgia (USA)
>

I concur with what Dr. Marchbein stated. This sounds like it was agranulocytosis which is a rare side effect of PTU. Whether or not the baby could be affected depends on a multitude of factors including such things as how high did the thyroid levels get while she was off PTU , and what is she on now, etc. These are questions that can only be answered by her Maternal-Fetal-Medicine Doctor.

-- R.Daniel Braun, MD

"Heisenberg might have slept here" Unknown or Indecisve

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