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Re: No ovulation on 50 mg. Clomid

From: Michele (anonymous@obgyn.net)
Fri, 7 Nov 1997 23:26:04 -0600 (CST)


At Wed, 5 Nov 1997, Garry E. Siegel, M.D. wrote: >
>At Wed, 5 Nov 1997, Michele wrote:
>>
>>I am 38, have been trying to get pregnant for over a year and have had a
>>history of irregular periods. I was prescribed 50 mg. Clomid for my
>>first cycle after a day 23 test was 11.9. I did not think that I
>>ovulated this month after taking the Clomid, and sure enough, my day 23
>>test came out 6.2. I had a very painful period last month and minor
>>pain throughout the month. I suspect a cyst(s), but my doctor has
>>simply prescribed 100 mg. for my next cycle without any exam.
>>
>>Two questions:
>>1. Is it 'normal' not to ovulate the first month on Clomid?
>>2. Should I be concerned about the possibility of cysts and will taking
>>100 mg. of Clomid help or hinder cysts if they exist?
>>
>>Thanks for your help.
>
>I am going to assume that your day 23 test done prior to getting Clomid
>was a serum progesterone, and that value may be indicative of ovulation.
>However, the 6.9 value is not indicative of ovulation, so it sounds like
>the Clomid didn't work. It is not unusual to need to go to a higher
>dose of Clomid, and most people do respond to 50 mg. or 100 mg.
>However, there are some other considerations about your situation,
>perhaps that have already been addressed.
>
>1. How irregular are your periods? Has your thyroid function (TSH test)
>and Prolactin been checked, as these can cause ovulation problems and
>are not corrected with Clomid.

They've been irregular for as long as I can remember, skipping up to 2-3 at a time. I was on the Pill for over 10 years to 'cure' my annovulation. My GYN at the time attibuted the cause to my low weight of 100 lbs. I went off of the Pill 2 years ago and after about 6 months, have had 'regular' periods every 32-40 days, but usually very light. >
>2. Again, I'm not convinced (given your data) that you are not
>ovulating. However, if your periods are infrequent, induction of
>ovulation (after testing as above) is reasonable.

Can I get a period if I do not ovulate? >
>3. You need to be taking a vitamin containing folic acid 0.4 mg.
I am taking a prescribed pre-natal vitamin. >
>4. Many people (including the American Society for Reproductive
>Medicine) recommend that anyone with infertility of more than 6 months
>after 35 see a reproductive endocrinolgist, who is an Ob/Gyn
>subspecialized in infertility management.

My OB/GYN is not specialized in infertility but her two partners are. I anticipate being referred to one of them if her initial suggestions don't 'work'. >
>5. I would generally want you to have blood tests on the third day of a
>spontaneous cycle to check your FSH and estradiol, which may give an
>indication of your ovarian reserve.

I will ask about this. >
>6. Have you had an HSG (hysterosalpingogram, or tubal dye test) and has
>a semen analysis been done?

No to the HSG. A semen analysis has been requested and will be completed before I take the next dose of Clomid. >
>7. Do you have any significant gyn history? Have you ever been
>pregnant?

No, I have never been pregnant. The only history that was significant to me was the diagnosis of a polycystic ovary during a sonogram after I complained of severe pain. That was over 10 years ago.

I appreciate all of the follow up questions, but my initial 2 questions have not been answered. If a 6.2 progesterone test proves that I have not ovulated, is it conclusive to say that the Clomid did not work and try again without being worred that something else is wrong?? My biggest concern are cysts, although reading other posts seem to indicate that cysts are a common occurrence and that they need not be worried about. >
>Good luck
>
>Garry
>no private emails/educational response only.
>
>--
>Garry E. Siegel, M.D., FACOG
>Private Practice
>Roswell, Ga.
>

--
Michele



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