WOMENS-HEALTH Messages for June, 1997: Re: HRTand breast CA risk

Re: HRTand breast CA risk

From: Laurie (anonymous@obgyn.net)
Fri, 27 Jun 1997 16:03:07 -0500 (CDT)

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At Thu, 26 Jun 1997, Janis wrote:

>My question with respect to this is: How does the dosage 50 ug relate to
>my 0.05 mg patch?

50 ug (micrograms) is equivalent to 0.05 mg (milligrams). This commonly pops up in dosing of levothyroxine or Synthroid, a thyroid hormone replacement: doseages are commonly written as "0.1 mg" or "100 ug," for example.

On 6/16 in this forum Dr. >Chudacoff expressed opinion that transdermal administration of estrogen
>bypasses the liver and decreases the effectiveness in respect to
>cardiovascular issues. I am curious about this perspective, but as yet
>have found no other mention

There are mixed opinions on this. In general it seems that the patch has the same effects as the pill but may take higher doses to achieve as great effects. Most people, however, consider the 0.05 mg patch an effective replacement dose. As with most medications, the lowest possible effective dose is what is recommended. You should probably be getting your lipids checked every three to five years, as well.

Do you see any reason not to augment my 0.05 mg patch >with a daily dose of soy?

No, I don't. Preliminary evidence shows good changes associated with soy related to lipid levels--favorable lipid profiles and decreased atherogenesis (in monkeys).

>
>I am also looking forward to more Raloxiphene data.

So am I. Hmmm, wonder if we should all buy some stock.... :-)

--
Laurie Lovely, MD
RE fellow, UNC-Chapel Hill

Next message: Laurie: "Re: Progesterone & Pregnancy"
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In reply to: Janis: "Re: HRTand breast CA risk"
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