WOMENS-HEALTH Messages for June, 1997: Re: Implantation and clomid

Re: Implantation and clomid

From: Kelly (anonymous@obgyn.net)
Tue, 3 Jun 1997 11:13:24 -0500 (CDT)

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At Tue, 3 Jun 1997, Sandra wrote: >
>My OB has told me that taking clomid can sometimes decrease the
>likelihood of implantation.
>
>Is there a way to monitor this? Is there any way to take action (drugs)
>that would decrease the "interference" caused by clomid?

Clomid can interfere with cervical mucus, so that the sperm cannot penetrate it. Intrauterine insemination is a way around this problem.

Clomid can also impair the endometrium (uterine lining), which may interfere with successful implantaion. this can be monitored by ultrasound and looking at endometrial thickness and the appearance of a tri-laminar pattern ("triple line sign"). My recent review of the literature (due to my own fertility problems), has shown mixed opinions regarding the treatment of this; some REs advocate supplemental estrogen, while others state it doesn't improve pregnancy rates. These REs suggest the use of Pergonal (or Fertinex ) for ovulation induction instead.

One again, I appeal to Dr. Lovely to give us her expert advice.

-- Kelly Shanahan, MD, FACOG S. Lake Tahoe, CA

note: Opinions here are for educational purposes only. This information is not intended to supplant the need for you to consult with your own physician. It cannot take the place of a face to face consultation and examination.

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