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Re: another HRT question

From: Catalin (anonymous@obgyn.net)
Sun, 1 Jun 1997 11:32:19 +0300 (GMT+0300)


On Sat, 31 May 1997, Joanne Bartling wrote:

> Geez, I hate to be a pest, and hog the forum, but all of these questions
> concerning ERT/HRT brought another question to my mind.
> I developed a rash to both arms, after my second dose of depo-provera,
> pill form. When I told my doctor I had an allergic reaction, he told me
> it was impossible, as it is produced naturally in my body. I've seen

Please tell to your doctor that the fact that progesterone is produced naturally in the body doesn't mean that it cannot induce an allergic reaction. In fact, there is a form of urticaria induced or aggravated by endogenous progesterone, patients with this form of urticaria experiencing urticarial eruption in the luteal phase of the cycle (usually premenstrual). Here are two references regarding this subject:

1. Mitman RJ, Bernstein DI, Steinberg DR et al. Progesterone responsive urticaria and eosinophilia. J Allergy Clin Immunol 1989; 84: 304-9.

2. Stephens CJM, Black MM. Perimenstrual eruptions: autoimmune progesterone dermatitis. Semin Dermatol 1989; 8: 26-9.

> enough drug reactions to recognize them well, enough, and I know I
> hadn't used anything new, or put anything on my arms for it to have been
> caused by something else.

It would be interesting to know what kind rash do you have. Is it urticarial?

It is also a little bit strange why it is limited to your arms. Do you have any idea or possible explanation for this?

> I do know a doctor, who is heavily involved with endo, is researching
> the theory that many of us, are indeed allergic to at least one of our
> hormones.

I think he is right (at least concerning progesterone).

> Knowing all of this, does it mean I could be allergic to all forms of
> progesterone?

I don't know the exact answer to this question. However, I think that NO would be a more appropriate answer.

I don't have any experience with depo-provera (not available here), but in theory you could become allergic not only to the progesterone molecule but to the other substances contained in depo-provera as well.

> Would I even need to worry about it. Would I likely just be put on
> estrogen after my 3-6 month waiting period, for any residual endo, to
> die off? Or would it be a combination of HRT?
> Any feedback would be appreciated. I'm 43 if that is a consideration.
> Thanks for your time.
>
> Joanne in NJ
>




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