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MENOPAUSE: Effects Of Tibolone In Older Postmenopausal Women From: Hope Waltman (anonymous@obgyn.net) Sat, 23 Aug 2008 07:44:45 -0500 (CDT) Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Tryn2concieve: "PREGNANCY: Plz help." Previous message: Hope Waltman: "FIBROIDS: Phase III Trials Of PGL4001 In Uterine Myoma" The Effects Of Tibolone In Older Postmenopausal Women "The recent report from the LIFT study1, a large, randomized, controlled trial of the hormone replacement therapy (HRT) tibolone in older postmenopausal women with osteoporosis, provides some good news and some bad news. This study has shown that: - Tibolone reduces the risk of osteoporotic fractures similar to other treatments such as HRT, bisphosphonates and raloxifene - Tibolone reduces the risk of invasive breast cancer similar to raloxifene and tamoxifen - The only significant adverse effect was an increased risk of stroke which was greatest in women over the age of 70 years - Tibolone should be used with caution in elderly women, where the potential benefit/risk ratio may be less than for younger women below the age of 70 years - The age at which hormone therapy is given is critical, as was also shown in the Women's Health Initiative (WHI) studies with the effects of conventional HRT" Reference 1. Cummings SR, Ettinger B, Delmas PD, et al. for the LIFT Trial investigators. The effects of tibolone in older postmenopausal women. N Engl J Med 2008;359:697-708 Regards, Hope Waltman, Fibroid Forum and WH Forum Moderator http://www.hopeforfibroids.org http://www.doctorsinfoweb.com/doctors.htm UTERINE FIBROIDS INFO: http://www.obgyn.net/fibroid-resource-center/ http://www.obgyn.net/fibroid-resource-center/?page=articles/patient_articles http://forums.obgyn.net/forums/womens-health/ Next message: Tryn2concieve: "PREGNANCY: Plz help." Previous message: Hope Waltman: "FIBROIDS: Phase III Trials Of PGL4001 In Uterine Myoma"

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