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Re: CONTRACEPTION: Extended- and continuous-cycle oral contraceptives

From: JoAnn NP (anonymous@obgyn.net)
Sun, 10 Aug 2008 12:25:26 -0500 (CDT)


At Sat, 9 Aug 2008, Hope Waltman wrote: >
> Pharmacotherapy. 2008 Aug;28(8):1033-40.Related Articles, Links
>Extended- and continuous-cycle oral contraceptives.
>
>Shrader SP, Dickerson LM. Department of Clinical Pharmacy and Outcome
>Sciences, South Carolina College of Pharmacy, Medical University of
>South Carolina, Charleston, South Carolina.
>
>Abstract Five new oral contraceptives, classified as extended- or
>continuous-cycle oral contraceptives, have been approved by the United
>States Food and Drug Administration. These agents have various
>combinations of estrogen and progestin, and different effects on the
>length of women's menstrual cycles. Usually they shorten the duration
>of menses, decrease the frequency of menses to 4 times/year, or
>completely eliminate menses. These new oral contraceptives are given in
>the following regimens: 24 days followed by placebo for 4 days (24/4),
>84 days followed by placebo for 7 days (84/7), or continuously (without
>placebo). These agents contain ethinyl estradiol 20 mug-drospirenone 3
>mg (24/4); ethinyl estradiol 20 mug-norethindrone 1 mg (24/4); ethinyl
>estradiol 30 mug-levonorgestrel 150 mug (84/7); ethinyl estradiol 30
>mug-levonorgestrel 150 mug (84/7) with very low-dose ethinyl estradiol
>(10 mug/day) for 7 days; and ethinyl estradiol 20 mug-levonorgestrel 90
>mug continuously.
>
>Clinical trials have demonstrated that extended- and continuous-cycle
>oral contraceptives are as effective in preventing pregnancy as
>traditional oral contraceptives. These new agents also have similar
>adverse effects; however, the only significantly different adverse
>effect compared with traditional oral contraceptives in clinical trials
>was change in bleeding pattern.
>
>These oral contraceptives are associated with more breakthrough bleeding
>and spotting than the traditional pills. Long-term effects on efficacy
>and safety are not known, as these new products generally have been used
>for only 1-2 years. Extended- and continuous-cycle oral contraceptives
>are a new option for women desiring decreased menses or for whom
>decreased menses may alleviate symptoms of coexisting medical
>conditions.
>
>http://www.ncbi.nlm.nih.gov/pubmed/18657019?dopt=Abstract
>
>Regards, Hope Waltman, Fibroid Forum and WH Forum Moderator
>
>http://www.hopeforfibroids.org
> http://www.doctorsinfoweb.com/doctors.htm
>UTERINE FIBROIDS INFO:
>http://www.obgyn.net/fibroid-resource-center/
>
>http://www.obgyn.net/fibroid-resource-center/?page=articles/patient_articles

Thank you for this valuable update.Symptom relief is a vital use of extended cycle use pills .JoAnn NP

--
Jo Ann  NP
Scottsdale, Arizona



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