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Re: CONTRACEPTION: Extended- and continuous-cycle oral contraceptivesFrom: JoAnn NP (anonymous@obgyn.net)Sun, 10 Aug 2008 12:25:26 -0500 (CDT)
At Sat, 9 Aug 2008, Hope Waltman wrote: > > Pharmacotherapy. 2008 Aug;28(8):1033-40.Related Articles, Links >Extended- and continuous-cycle oral contraceptives. > >Shrader SP, Dickerson LM. Department of Clinical Pharmacy and Outcome >Sciences, South Carolina College of Pharmacy, Medical University of >South Carolina, Charleston, South Carolina. > >Abstract Five new oral contraceptives, classified as extended- or >continuous-cycle oral contraceptives, have been approved by the United >States Food and Drug Administration. These agents have various >combinations of estrogen and progestin, and different effects on the >length of women's menstrual cycles. Usually they shorten the duration >of menses, decrease the frequency of menses to 4 times/year, or >completely eliminate menses. These new oral contraceptives are given in >the following regimens: 24 days followed by placebo for 4 days (24/4), >84 days followed by placebo for 7 days (84/7), or continuously (without >placebo). These agents contain ethinyl estradiol 20 mug-drospirenone 3 >mg (24/4); ethinyl estradiol 20 mug-norethindrone 1 mg (24/4); ethinyl >estradiol 30 mug-levonorgestrel 150 mug (84/7); ethinyl estradiol 30 >mug-levonorgestrel 150 mug (84/7) with very low-dose ethinyl estradiol >(10 mug/day) for 7 days; and ethinyl estradiol 20 mug-levonorgestrel 90 >mug continuously. > >Clinical trials have demonstrated that extended- and continuous-cycle >oral contraceptives are as effective in preventing pregnancy as >traditional oral contraceptives. These new agents also have similar >adverse effects; however, the only significantly different adverse >effect compared with traditional oral contraceptives in clinical trials >was change in bleeding pattern. > >These oral contraceptives are associated with more breakthrough bleeding >and spotting than the traditional pills. Long-term effects on efficacy >and safety are not known, as these new products generally have been used >for only 1-2 years. Extended- and continuous-cycle oral contraceptives >are a new option for women desiring decreased menses or for whom >decreased menses may alleviate symptoms of coexisting medical >conditions. > >http://www.ncbi.nlm.nih.gov/pubmed/18657019?dopt=Abstract > >Regards, Hope Waltman, Fibroid Forum and WH Forum Moderator > >http://www.hopeforfibroids.org > http://www.doctorsinfoweb.com/doctors.htm >UTERINE FIBROIDS INFO: >http://www.obgyn.net/fibroid-resource-center/ > >http://www.obgyn.net/fibroid-resource-center/?page=articles/patient_articles Thank you for this valuable update.Symptom relief is a vital use of extended cycle use pills .JoAnn NP
-- Jo Ann NP Scottsdale, Arizona
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