WOMENS-HEALTH Messages for January, 2008: Re: PCOS: Ovarian disorder linked with early heart disease

Re: PCOS: Ovarian disorder linked with early heart disease

From: Walter Futterweit, MD, FACE,FACP (anonymous@obgyn.net)
Mon, 7 Jan 2008 21:33:42 -0600 (CST)

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Risk of Coronary Artery Disease in Mothers of Women with PCOS Kai I Cheang (author), John E Nestler and Walter Futterweit

The Endocrine Society's 89th Annual Meeting Abstract presented in Toronto June 4th 2007

PCOS have a higher prevalence of cardiovascular disease (CAD) risk factors (e.g. dyslipidemia, hypertension and diabetes), and subclinical CAD (coronary calcification and carotid intimamedia thickness), as compared with normal women. While several studies reported higher risks of CAD and fatal myocardial infarction (MI)in PCOS, death certificates of PCOS women in UK did not show increased CAD mortality compared with actuarial tables. The purpose of this study was to assess the prevalence of CAD in postmenopausal PCOS women. To capture such a population, the presence of CAD in PCOS and non-PCOS mothers of women with PCOS was determined.

270 women with PCOS were surveyed about their mothers’ medical history. The survey covered menstrual history, fertility, clinical signs of hyperandrogenism, onset of CAD risk factors (e.g. hypertension, dyslipidemia, diabetes), age of incident CAD, fatal and non-fatal MI, and age of death. About 60% of the daughters’ initial history was verified by personal interviews with the mothers. Presence of PCOS in the mothers was defined as relative difficulty in achieving pregnancy, presence of irregular menses, and clinical signs of hyperandrogenism. Presence of CAD was defined as any percutaneous coronary intervention, angina that necessitated emergency room visits, or fatal or nonfatal MI.

Among the 270 women with PCOS, 60 had mothers with probable PCOS while 210 mothers did not meet the PCOS criteria. Complete cardiovascular history was successfully obtained from 39 PCOS mothers and 75 normal mothers. The mean age of PCOS mothers at the time of survey did not differ from that of non-PCOS mothers (58.6 + 1.3 vs. 58.6 + 0.7, respectively). Including only those mothers whose cardiovascular histories were available, 13 of 39 (33.3%) PCOS mothers had CAD compared with 1 of 75 (1.3%) normal mothers (p<0.0001). Eight of 39 (20.5%) PCOS mothers had suffered an MI compared with 1 of 75 (1.3%) normal mothers (p<0.0001). Notably, all PCOS mothers who had an MI were 65 years old or younger at the time of their incident MI.

Conclusion: PCOS mothers of women with PCOS are at a higher risk of CAD events compared with non-PCOS mothers, and MI appears to occur at an earlier than expected age in PCOS mothers.

At Mon, 7 Jan 2008, Walter Futterweit, MD, FACE,FACP wrote: >
>Mrs Waltman submitted an important article, which stresses the
>need for vigilance and early diagnosis of PCOS.
>Futher studies in a combined study from the University of Virginia and
>the Mount Sinai School of Medicine of 308 women is in progress.
>A frequent contributor to cardiovascular EVENTS not just risks of
>308 mothers, about 25% of whom have PCOS,many of whom are overweight or
>obese is currently being done.
>Dr.Futterweit
>
>At Mon, 7 Jan 2008, Hope Waltman wrote:
>>
>>January 4, 2008
>>"NEW YORK (Reuters Health) - Relatively young women who are obese and
>>who have polycystic ovarian syndrome are at increased risk of developing
>>coronary atherosclerosis, also referred to as "hardening of the
>>arteries," which is unrelated to other known risk factors for heart
>>disease, a new study shows."
>>SOURCE: Journal of Clinical Endocrinology and Metabolism, December 2007.
>>
>>http://www.nlm.nih.gov/medlineplus/news/fullstory_59678.html
>>
>>Hope, WH Forum Moderator
>
>--
>Walter Futterweit, MD, FACP, FACE
>Clinical Professor of Medicine, Division of Endocrinology
>Mount Sinai School of Medicine, New York, NY 10029
>http://www.aacehost.com/pages/page.php?r=716
>

--
Walter Futterweit, MD, FACP, FACE
Clinical Professor of Medicine, Division of Endocrinology
Mount Sinai School of Medicine, New York, NY 10029
http://www.aacehost.com/pages/page.php?r=716

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