WOMENS-HEALTH Messages for August, 2007: Re: FIBROIDS: 3 miscarriages

Re: FIBROIDS: 3 miscarriages

From: Walter Futterweit, MD, FACE,FACP (anonymous@obgyn.net)
Sat, 4 Aug 2007 18:18:20 -0500 (CDT)

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In reply to: anonymous@obgyn.net: "FIBROIDS: 3 miscarriages"

At Fri, 3 Aug 2007, anonymous@obgyn.net wrote: >

I agree with Dr. Van Alman about the significance of fibroids only when shown to be affecting the lining of the endometrium and its location and size. Your story is very touching and allow me to make the following comments. If your endocrinologist feels you have PCOS and his opinion confirmed by an expert in the field, the presence of recurrent miscarriages is fairly common in the syndrome. Insulin resistance (IR) is common in PCOS worsens in pregnancy, and it may be wise to take at least 1500mg metformin daily (and not the 750 ? mg you took for only 1 year, a while ago). Controlling the IR prior to pregnancy is very important, as is checking thyroid function and other entities with pregnancy, namely the antiphopholipid syndrome. Since you are at great risk for miscarriage a reproductive OBGYN endocrinologist should see you. This is important. The continuation of meformin during pregnancy for the first 3 months, or perhaps for the entire pregnancy, is in my view important. It exerts effects not only for the IR but has helpful effects on the uterine hormnoes as well in maintaining the status of the fertilized egg in the uterus. Look at Pub Med articles by Dr. John Nestler on this and others. Wishing you the best, Dr.Walter Futterweit Clinical Professor of Medicine Division of Endocrinology Mount Sinai School of Medicine New York, NY 10029

>2 years ago I went to visit my OB/GYN to because my husband and wanted
>to start having more kids and to find out why I have not had a period in
>1 year since I was off BCP. I was diagnosed with PCOS and I was not
>ovulating or getting my period, hair growth, weight gain, . My doc
>started me with 5 pills of clomid first and then a year worth of 750mg
>of metoformin. I got my period 3 weeks from taking the meds. 6 months
>later I missed my period which was due end of Nov., Dec nothing Jan. to
>preg test it was light. Went on with mylife. Feb. 14, started
>bleeding thought it was a period then I drop clots. Turns out i was 11
>1/2 pregnant, which i missed carried. 7 month later pregnant again in
>Nov 06, test was light, started bleeding 7weeks. Miscarried. Was sent
>to infertility specialist he suggest it could many factors, but the main
>hormonal inbalance, gave me progestrone suppository to use when i find
>that i am pregnant. 7 1/2 mo. later June 28 07 spotting brown, preg
>test positive a little light. Date of last period May25 07,took supp.
>until appt. with doc. Had five hcg test in 5 week levels keep going up
>but not high enough to be prenangy. Had ultra sound and vaginal
>ultrsound. Just a sac on right side of uterus. told to stop supp. and
>take another hcg in week did levels still going up, had ultra sound
>nothing, then july 30 started heavy bleeding then and losing tissue.
>Question I have a fibroid on oustide of uterus located near navel it was
>from my first baby and I have history of cyst in ovaries. Is this the
>cause of my miscarriages? Why do i get preg every 7month and then lose
>it every 7 weeks? Truly heartbroken, confused and hoplessness.

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