WOMENS-HEALTH Messages for March, 2007: Re: UROGYNECOLOGY: Norfloxacin and Pregnancy

Re: UROGYNECOLOGY: Norfloxacin and Pregnancy

From: Pat Sonnenstuhl (anonymous@obgyn.net)
Tue, 27 Mar 2007 09:27:21 -0500 (CDT)

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In reply to: Sonja: "UROGYNECOLOGY: Norfloxacin and Pregnancy"

It is rather odd that your provider would presecribe this medication for an infection when there are other drugs available with less risk. AT this point in time there isn't anything that can be done, but wait and see how things work out. It appears it is fairly safe, and just has not been well researched in regards to pregnancy. That is the main concern, not that it has caused anything specific in a growing pregnancy. Here are several articles that you might find informative. Pat

<<http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a687006.html<<

Pregnancy

Teratogenic Effects. Pregnancy Category C. Norfloxacin has been shown to produce embryonic loss in monkeys when given in doses 10 times*** the maximum daily total human dose (on a mg/kg basis). At this dose, peak plasma levels obtained in monkeys were approximately 2 times those obtained in humans. There has been no evidence of a teratogenic effect in any of the animal species tested (rat, rabbit, mouse, monkey) at 6-50 times*** the maximum daily human dose (on a mg/kg basis). There are, however, no adequate and well-controlled studies in pregnant women. Norfloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. >>http://www.rxlist.com/cgi/generic/norfloxacin_wcp.htm

At Tue, 27 Mar 2007, Sonja wrote: >
>Hi. After years of trying, I am two weeks pregnant following IVF. Last
>week I has a UTI and my doctor gave me Norfloxacin. My doctor knew I
>might be pregnant. Since then, I have been told this drug is
>contraindicated in pregnancy. I'm worried sick. What are the chances I
>have harmed my baby?

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