WOMENS-HEALTH Messages for January, 2003: Re: Premarin & Ovarian Cancer

Re: Premarin & Ovarian Cancer

From: Helen (anonymous@obgyn.net)
Sun, 12 Jan 2003 10:34:19 -0600 (CST)

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At Fri, 10 Jan 2003, Rebecca wrote: >
>>Why, after 24 years, had ovarian cancer cells proliferate inside her diaphragm? Her presentation of a left DVT and PE in 1972 (DVT is not uncommon in patients with ovarian cancer and it may be a presenting sign) enabled the doctors to find her ovarian cancer at it's earliest stage where just surgical oncology alone is over 93% curative. Her postoperative chemotherapy was among the slowest acting and least toxic of the alkylating agents whereas the depression of the immune system was slow and reversible, allowing it to regenerate and contribute to healing her cancer. Plus, she was only 40 years of age.
>
>My wife had been taking Premarin for over twenty years. That's right! Premarin. This past summer, the National Institutes of Health had published articles about two large studies indicating the increased risk of ovarian cancer linked to Estrogen Replacement Therapy. For women who used estrogen for 20 years or more it was increased by more than 300% (3-fold) compared to women who had never taken it.
>
>Gregory D. Pawelski
>
>Ann's Story: http://pathology2.jhu.edu/ovca/story.cfm?PersonID=33
>?

I'm not sure what your point is, but the NIH did NOT publish any study on Premarin last summer. The FDA did recently publish a warning to assume Premarin (and all hormone treatments) are dangerous until proven otherwise.

However, I have a problem with your charge that Premarin caused her second bout with ovarian cancer. She wasn't taking it when she got the disease in the first place. Cancer often returns years later, unfortunately. And you can have ovarian cancer after ovaries are removed and w/o even taking Premarin. The fact that your wife is still alive over 30 years after first being diagnosed with ovarian cancer is miraculous. Lots of women take Premarin without any ill effects, and for short periods at small doses it greatly improves the quality of life for many women. As far as taxol goes, many of my friends are most likely alive today because of it, so I disagree with you wholeheartedly. One must always carefully evaluate the risks and benefits of any treatment as it applies to their own unique circumstances.

--
Helen

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