WOMENS-HEALTH Messages for August, 2002: Re: Aygestin, Testosterone, Bleeding

Re: Aygestin, Testosterone, Bleeding

From: Victoria (anonymous@obgyn.net)
Sat, 31 Aug 2002 09:29:18 -0400

Messages sorted by: [ date ][ thread ][ subject ][ author ]
Next message: Dr.: "Re: Help Syndrome and severe Pre Eclamcia"
Previous message: Anonymous: "Important"
Maybe in reply to: Janise: "Aygestin, Testosterone, Bleeding"

Please see http://www.quackwatch.com, and http://nicho_v.tripod.com/research.html, along with my previous posts at http://forums.obgyn.net/womens-health/WHF.0208/0104.html for information on the FDA going after companies promoting progesterone cremes. See http://www.quackwatch.com/01QuackeryRelatedTopics/wildyam.html (pieces I put below) and Dr. Mark Perloe's (http://www.ivf.com, he's a reproductive endocrinologist who is highly regarded) comments regarding skin/progesterone cremes. If you do take a chance on it and it doesn't work, please let the FDA know.

In premenstrual syndrome, for example, double-blind controlled trials have demonstrated that progesterone supplementation is no better than a placebo. Also blatantly false is the claim that synthetic progestins are dangerous whereas natural progesterone is harmless. Progesterone in any form may cause side effects.

Also left unmentioned is the fact that, once introduced into the body by any effective means (including through the skin), the progesterone molecule can be metabolized to a wide variety of other compounds including estrogens, androgens, and even corticosteroids. Indeed, all of these vital hormones are the products of the continuous production of progesterone and its physiologic conversion of in the ovaries, testes, and adrenal glands. Part of the usefulness of synthetic progestins, on the other hand, is that they are not subject to these biochemical pathways but are able to exert their desired effects until metabolized and excreted.

http://forums.obgyn.net/ob-gyn-l/OBGYNL.0205/0317.html Topical progesterone can be wonderful. 95% is metabolized to hydroxyprogesterones with little protective effect. Yet, these metabolites can bind to the Cl ion channel, like valium. Salivary and serum progesterone correlations tend to be quite high.

http://forums.obgyn.net/ob-gyn-l/OBGYNL.0207/0039.html Giving topical progesterone is worthless plain and simple. There are very large amounts of 5 alpha reductase in the skin which will metabolize up to 98% of any P administered topically. But they will feel good, since the 5 alpha reduced progesterone will bind to the Cl ion channel receptor, the same place valium binds.

--
Victoria

Next message: Dr.: "Re: Help Syndrome and severe Pre Eclamcia"
Previous message: Anonymous: "Important"
Maybe in reply to: Janise: "Aygestin, Testosterone, Bleeding"

Women's Insurance Checklist from Auto Insurance Quote

use when must restrict search to only the women's health forum...
Enter search keywords:
	Returns per screen: Require all keywords: