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Re: to BJ about progest creamFrom: BJ (anonymous@obgyn.net)Thu, 18 Apr 2002 13:08:27 -0500 (CDT)
At Thu, 18 Apr 2002, anonymous@obgyn.net wrote: > >BJ, you have me totally confused! I read, at Dr. Rick's website >http://www.wdxcyber.com >that it is actually progesterone (I don't remember whether he said alone >or in addition to estrogen) which causes fibroids to increase/grow in >size?!? >I may also consider trying out the progesterone cream (just got off bc >pill a few months ago and STILL have not had a period). I, too, have a >history of endo/endo surgery. I am not surprised at your confusion. lots of that going around! Is this the information you read on that site? "As far as uterine fibroids go, the present theory regarding their development is that neoplastic transformation of normal muscle cells occur under the influence of many hormones, including E and P. Fibroids have receptors for both E and P. The exact stimulus for growth is UNCLEAR but may be related to relative levels of E and P." The last sentence refers to relative levels. That is what I have come to believe. The progesterone level is too low to balance the estrogen level so it is the estrogen, in my opinion, that causes the fibroid growth and the progesterone that inhibits it. What this says about receptors is also said about breast cancer but a receptor does not necessarily mean that the particular hormone causes growth. Binding of progesterone to progesterone receptors causes inhibition of growth.
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