WOMENS-HEALTH Messages for August, 2001: Re: HPV?-Reply to Dr. Marchbein...!

Re: HPV?-Reply to Dr. Marchbein...!

From: Melanie (anonymous@obgyn.net)
Sun, 26 Aug 2001 17:28:40 -0500 (CDT)

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Reply: Harvey S. Marchbein, M.D.: "Re: HPV?-Reply to Dr. Marchbein...!"

Thanks VERY much for your response.

The colposcopy/biopsy was supposedly done to confirm the HPV diagnosed (or misdiagnosed) at the first Pap screening (an HPV DNA panel was done at that time....low-risk was supposedly the outcome....)

QUESTIONS:

1) Does the biopsy diagnosis of <<Parakeratotic squamous mucosa with parabasal cell hyperplasia>> confirm HPV? My gut sense is it does NOT....And that's why you're suggesting the HPV cervical sample....(AND, if this test you're suggesting is different from the HPV DNA panel that's already been done, it stands to reason it should have been done on the tissue samples from the biopsy, if the Dr. ORDERED the biopsy to confirm HPV!!! I shouldn't have to go back for it, if you know what I mean!)

2) PLEASE translate <<Parakeratotic squamous mucosa with parabasal cell hyperplasia>> into simple layman's language. I need to know what it means.

(PS...I live on Long Island as well. My breast surgeon is in Lake Success, Karen Kostroff....)

Again, thank you very much for your response....

At Sun, 26 Aug 2001, Harvey S. Marchbein, M.D. wrote: >
>Simple answer. Get an HPV low risk/ high risk cervical sample to get
>the answer rather than debate the possibilities. Once that is back, the
>discussion can begin.
>
>Hope this helps and write back anytime for more information.
>
>HSM
>
>At Sun, 26 Aug 2001, Melanie wrote:
>>
>>At Wed, 22 Aug 2001, Melanie wrote:
>>>
>>>At my yearly pap screening brief, I was told that HPV was
>>>found on the cervix. I then went for a colposcopy/w biopsy; two
>>>"abnormal" spots were sampled, but no veneral warts were seen. The path
>>>report for the biopsy doesn't specifically mention HPV, but states a diagnosis
>>>of <<Parakeratotic squamous mucosa with Parabasal cell Hyperplasia>>
>>>
>>>Is this diagnosis consistent with HPV? Or is this just
>>>normal cytology for a 47 year old female?
>>>
>>>Considering the Abadi & Ho et al paper on overdiagnosis
>>>of HPV, (Abadi MA; Ho GY; Burk RD; Romney SL; Kadish AS. Stringent
>>>criteria for histological diagnosis of koilocytosis fail to eliminate
>>>overdiagnosis of human papillomavirus infection and cervical
>>>intraepithelial neoplasia grade 1. Hum Pathol 1998;29(1):54-9), I have
>>>reason to wonder.

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