WOMENS-HEALTH Messages for March, 2001: Re: #3 - my 11 yr old was just diagnosed with polycystic ovary syndrom

Re: #3 - my 11 yr old was just diagnosed with polycystic ovary syndrom

From: Harvey S. Marchbein, M.D. (anonymous@obgyn.net)
Fri, 9 Mar 2001 10:58:56 -0600 (CST)

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Premature adrenarche: findings in prepubertal African-American and Caribbean-Hispanic girls. Acta Paediatr Suppl 1999 Dec;88(433):67-72 (ISSN: 0803-5326) Dimartino-Nardi J Division of Pediatric Endocrinology, Montefiore Medical Center, Bronx, New York 10467, USA. jdpedendo@aol.com.

The term 'syndrome X' refers to the constellation of laboratory and clinical findings associated with hyperinsulinism stemming from insulin resistance. These findings include obesity, acanthosis nigricans, glucose intolerance, type 2 diabetes mellitus, dyslipidaemia with reduced HDL and elevated low-density lipoprotein, cardiovascular disease and PCOS. Hence, for certain girls, premature adrenarche may be a part of the clinical spectrum of syndrome X.

Ovarian responses to hCG stimulation: insulin resistance/hyperinsulinaemia vs. insulin deficiency. Clin Endocrinol (Oxf) 1999 Jul;51(1):127-30 (ISSN: 0300-0664) Witchel SF; Arslanian S Division of Paediatric Endocrinology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.

This case report confirms that insulin resistance/hyperinsulinaemia exacerbates ovarian hyperandrogenism.

Hope these articles give you a jump off point for discussions with your daughter's doctor. These three posts are the latest literature and in 3 large posts, you've just gotten the basics. Visiting the PCO section at OBGYN.net will also be helpful.

--
Harvey S. Marchbein, M.D. FACOG, FACS
Great Neck, New York

**Note:  Opinions expressed here are for educational purposes only
and, as such, do not constitute a physician-patient relationship.
This information is not intended to supplant the need for you to
consult with your physician prior to choosing therapeutic options
and/or interventions.

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Next message: Mel: "regarding vagina smell"
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