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Re: LOCAH vs PCOSFrom: Nancy (anonymous@obgyn.net)Fri, 24 Nov 2000 05:41:19 -0600 (CST)
At Thu, 23 Nov 2000, R. Daniel Braun, MD wrote: > >At Thu, 23 Nov 2000, Nancy wrote: >> >>Are Late Onset Congenital Adrenal Hyperplasia and Polycystic Ovary >>Syndrome related? I know they have many of the same symptoms. It was >>suggested to me that I could have PCOS although I know based on sono and >>several laparoscopies that I don't have polycystic APPEARING ovaries. I >>have had a long hx of ovulation pain which at one time was severe and >>lasted for days. At age 43, I have insulin resistance with fairly >>normal blood sugars most of the time, regular periods every 25-28 days, >>very mild acne which seems related to my cycle, elevated LDL, Total >>CHOL, mediocre HDL and ok triglycerides. Have one recurrent chin >>whisker and an occasional lower abdominal stray hair but certainly >>nothing that qualifies as hirsiutism. I controlled my weight with diet >>and exercise when I was younger but now am 50 lbs overweight and it >>won't budge! My 8 yr old daughter has gained 45 lbs in 3 yrs (previously >>in 5th percentile) and has developed pimples on her forehead nose and >>chin with a few on her cheeks at times- at any given time she will have >>as many as 10-15 (mostly whiteheads in varying stages)on her face. Much >>of her weight gain has been truncal although her arms are chubbier and >>her legs pretty solid/stocky. She is being worked up by an endo and I >>guess based on the tests he ordered, he is looking for either Cushings >>or LOCAH. I asked if PCOS was ever diagnosed in a child and he said >>usually not til after puberty. I'm wondering if our problems are likely >>to be related? Do PCOS and LOCAH run in the same families commonly or >>would we be likely to have the same disorder? I know my Mom had periods >>from Hell and tried for 8 yrs to have her first child. None of us have >>hirsuitism though. Hypothyroidism also runs in family. Thanks for any >>insight you can provide. >> >>-- >>Nancy >> >They are probably not related. >We are learning a lot more about PCOS than we had any idea existed. It >is only over the last 5-10 years that we learned about Insulin >resistance as part of PCOS. It is possible to have PCOS without having >polycystic ovaries. My doctor says the drug companies that make the drugs which lower insulin resistance tell him they are not indicated yet for people who do not have elevated blood sugars. I have understood that elevated insulin levels alone can be atherogenic and my lipid profile is not ideal either. Although I usually have a FBS of appx 120 (occasionally as high as 139), my HgbA1c is 5-6. Do I sound like a candidate for metformin if I indeed test positive for PCOS? He didn't want to even test my hormone levels because he said there was really nothing to treat in my case. I noted in one article by Dr. Mark Perloe that metformin did not lower glucose levels in non diabetic women but did lower insulin levels and decreased the feelings of hypoglycemia. That led me to believe that metformin would be a reasonable treatment for me. If so, is it worth the potential side effects?
Also, do you think an 8 yr old could possibly develop some symptoms of
PCOS at such an early age- she has no signs of puberty yet.
>
-- Nancy
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