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Longstanding undiagnosed problem- PCOS? Hypothyroid?From: Nancy (anonymous@obgyn.net)Fri, 10 Nov 2000 19:21:52 -0600 (CST)
Currently I have insulin resistance, slightly elevated cholesterol with increased LDL, HDL around 40, and normal triglycerides. 43 years old and 50 lbs overweight for last few years. Cycles are 25-28 days occuring monthly. Frequently have mild pain with ovulation (can feel every footstep I take in my ovary). Had 3 closely spaced pregnancies with preterm labor beginning early and diagnosed by 20 weeks each time, requiring double tocolytics. Also had gestational diabetes each time requiring insulin. At age 18 I started having severe,excruciating pain every month immediately FOLLOWING my period and lasting until about the time of ovulation. This pain usually only lasted from about 1 or 2 AM until about 6 or 7 AM. I would go to sleep feeling ok and be awakened by pain that caused me to writhe in the bed. Pain also ended pretty abrubtly but would reoccur the following night for a week to 10 days! Eventually had a laparoscopy which did not reveal the cause. Later a sono found a cystic appearing mass in the lower left posterior wall of my uterus. Later evaluated by reproductive endocrinologist who thought by sono that it was a fibroid but then on lap and hysteroscopy, could not detect it and it was near major uterine arteries which he did not want to risk exploring, knowing I planned another pregnancy (after 1st child). He mentioned on the operative report, "normal appearing ovaries. Corpus luteum in left ovary." I was taking Synarel at the time of this surgery because he wanted to shrink what he thought was a fibroid and planned to remove it. This weird pain syndrome responded immediately (first cycle) to both Danazol and Synarel, although I had been told it would take a few months to even notice a difference. Had BTL 1 yr after 3rd child and lots of adhesions were noted but no mention of anything else abnormal. Have had few problems with cycle since then other than worsened PMS. For the last few years I've had fatigue, weight gain, often feel cold, dry skin everywhere except face and upper trunk, hair now starting to come out enough for hairdresser to mention. Several years after these symptoms, I've developed a thyroid nodule-mostly cystic. TSH 0.85, T4, T3U Thyroxine index all mid range. Free T3 and Free T4 near bottom of normal range. Does any of this sound like it could be PCOS despite "normal appearing ovaries"? Why the thyroid nodule and normal labs with hypo symptoms? Also, my Mom is treated for hypothyroidism for 25 years following 2/3 removal of her thyroid for a benign nodule. With this treatment, her weight dropped 50 lbs, glucose and cholesterol normalized in 6 months. She also tried to get pregnant for 8 years before success and had long history of painful very heavy periods. Also currently have 8 year old daughter with sudden onset of significant weight gain over past 3 years and she now has acne- she's seeing an endo next week. Sorry this is so long but no one has ever been able to find anything wrong with us and this seems very abnormal to me and I think it must all be related. Hope someone can give me some ideas to at least get checked out.
-- Nancy
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