WOMENS-HEALTH Messages for August, 2000: Re: 35 years old...do risks out weigh benefits?

Re: 35 years old...do risks out weigh benefits?

From: R. Daniel Braun, MD (anonymous@obgyn.net)
Thu, 24 Aug 2000 20:20:34 -0500 (CDT)

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In reply to: jhc: "35 years old...do risks out weigh benefits?"

At Thu, 24 Aug 2000, jhc wrote: >
>Hello,
>I am 35 years old (nearly 36) and I am thinking about trying one more
>round of IVF. I have had one successful pregnancy at the age of 33
>through IVF. I realize that the chances of chromosomal disorders
>increases at or above age 35. Do the risks of chromosomal disorders out
>weigh the benefits of a potential healthy pregnancy. What is the risk
>of a chromosomal disorder at age 36?
>I have a neice (my brother's daughter) that was born with Down's
>syndrome. Her mother was age 33 at the time of her birth and my brother
>was 30. Is Down's (and other chromosomal disorders) always associated
>with the age of the mother? Does having a neice with Down's increase my
>chances of also having a child with a chromosomal disorder?
>
>Any info would be helpful.

The risk of chromosomal disorders increases every year. it is greater at 21 than it is at 20, etc. Age 35 is the age at which the risk of a Chromosomal anomaly (1 in 365 pregnancies) becomes greter than the risk of amniocentesis causing a miscarriage. Or at least that was the case 25-30 years ago. Risk of a miscarriage from amnio has decreased with better ultrasound and technique. But age 35 has been ingrained and that is still the "cutoff age". At age 40 it is 1 in 100 and at age 45 about 1 in 40 and at age 49 about 1 in 9. All those are approximate as I remember them. I don't have the table here at home to look them up exactly, but this will give the idea. The risks of high blood pressure causing problems also increases as age increases. IVF with Donor eggs would not have an age related increase in chromosome anomaly risk. Actually it is age related to the donors age.

RDB

--
R. Daniel Braun, MD FACOG  FOG

This is for educational purposes only, and is not intended to be replacement or substitute for consultation and examination by an appropriate medical professional.  Due to time constraints, private e-mails cannot be answered.

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