WOMENS-HEALTH Messages for July, 2000: Re: PCO-Placed on Clomid and Nolvadex?

Re: PCO-Placed on Clomid and Nolvadex?

From: Lynn D. Montgomery, MD (anonymous@obgyn.net)
Wed, 5 Jul 2000 23:07:50 -0500 (CDT)

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In reply to: Veronica: "PCO-Placed on Clomid and Nolvadex?"

At Wed, 5 Jul 2000, Veronica wrote: >
>I have PCO and am trying to have a baby. OB/Gyn placed me on
>Serephene 100mg/day and Nolvadex 20mg/day for 5 days. Day 1
>being first day of my period. My question is Nolvadex (Tamoxifen) is a
>breast cancer drug. Why would I need to take this? Does it have
>anything to do with hormone levels?
>If anyone can give me some idea I'd be greatful.
>
>Confused?
>
>--
>Veronica
>

Veronica, Tamoxifen is an estrogen receptor blocker. I have to be honest, I have not seen this combination. Serophene also acts by blocking the estrogen receptors in the hypothalmus and pituitary. This has the affect of fooling the body into thinking that there isn't any estrogen (which is usually produced by a developing egg) being produced and in turn the hypothalmus and pituitary will produce more follicle stimulating hormone (FSH), which in turn intensifies the recruitment of an egg(s) from the ovaries, therefore inducing ovulation.

My guess is that the tamoxifen is given to intensify this response... Lynn

--
Lynn D. Montgomery, MD
Director, Maternal-Fetal Medicine
Rocky Mountain Perinatal Center
Missoula, Montana

**Note:  Opinions expressed here are for educational purposes only and, as such, do not constitute a physician-patient relationship.  This information is not intended to supplant the need for you to consult with your physician prior to choosing therapeutic options and/or interventions.

**Private e-mails cannot be entertained due to time constraints, consequently no private e-mails will receive a response.

**Thank you for your understanding ;-)

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