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Re: microcephaly-15th May 99 From: art fougner, md (evsono@pipeline.com) Mon May 17 10:05:11 1999 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Tracy L. Trull: "[Fwd: ]" Previous message: art fougner, md: "Re: microcephaly-15th May 99" In reply to: DR.JOE ANTONY: "Re: microcephaly-15th May 99" Joe, here's another article you may wish to look at - Correlation of fetal frontal lobe and transcerebellar diameter measurements: the utility of a new prenatal sonographic technique. Ultrasound Obstet Gynecol 1997 Aug;10(2):94-7 (ISSN: 0960-7692) Persutte WH; Coury A; Hobbins JC [Find other articles with these Authors] Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262, USA. Several authors have reported the value of the sonographic assessment of both the fetal frontal lobe and the cerebellum. Both frontal lobe shortening and cerebellar hypoplasia have been associated with fetal aneuploidy. We anecdotally observed that the distance between the calvarium and the posterior cavum septum pellucidum (frontal lobe) closely approximated the transcerebellar diameter. This study was undertaken to investigate this relationship. Between 1 July 1994 and 1 January 1996, the frontal lobe (posterior cavum septum pellucidum to the inner calvarium) and transcerebellar diameter were measured in patients referred to two prenatal ultrasound laboratories in Denver, Colorado, USA. All pregnancies had certain dates and were uncomplicated. Statistical comparison was completed using interval polynomial regression analysis. During the study period, we performed 221 detailed ultrasound examinations in which the frontal lobe and the transcerebellar diameter were measured. We found a correlation coefficient of 0.950 when comparing the two variables (p < 0.0001). Some conditions (Down's syndrome, lethal trisomies and pathological microcephaly) have differential effects on the frontal lobe and the transcerebellar diameter. Our preliminary judgement is that this new technique may prove to be a useful tool in assessing the relative effect of these conditions on structural neuroanatomy. again, good luck and keep us posted. Art At Sat, 15 May 1999, DR.JOE ANTONY wrote: > >Dear Terry, >I donot have all the data you asked for. Here is what I have: > >-23yr. old female patient: >BPD:73mm >FL :63mm >HC :286 mm >AC :335 mm >OFD:100 mm >The presentation is cephalic. >Placenta is fundic and posterior. >No other anomalies were seen. > >Thanks for all the attention and interest from your side. >Regards, >DR.JOE ANTONY -- art fougner, md SonoScan/Genetic Sciences forest hills, ny evsono@pipeline.com Next message: Tracy L. Trull: "[Fwd: ]" Previous message: art fougner, md: "Re: microcephaly-15th May 99" In reply to: DR.JOE ANTONY: "Re: microcephaly-15th May 99"

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