Re: Research Projects was Re: Yolk sac

From: Joseph A Worrall (jworrall@alaska.net)
Sun Jan 31 11:45:46 1999


I do not think dealing with inside and outside measurements of the yolk sac would be worthwhile.

I am not familiar enough with the work that has been done on the yolk sac to know how definitive it is: is the finding of a large yolk sac early in the first trimester have the same specificity, sensitivity, PPV and NPV as the nuchal translucency work, or is it more like the middle phalanx of the fifth finger?

I would agree with you if we really can say the work has already been done. I think I have Dr. Lyons' paper in my files, and I will have to read it again.

As you say, perhaps we should just request that folks who come across a yolk sac greater than 6 mm inner diameter at 8 weeks or less, please report the case when the outcome is known. And we could ask Kevin to keep these cases posted in a special area.

At least, we have begun to think about the potential: I have mentioned before that I am awed when I think that Beryl Benaceraff's lab does 80 prenatal scans per day. No wonder she can publish so much on so many prenatal things+ACE- We need some idea of how many prenatal scans +ACI-we+ACI- (meaning our online community, whatever that is) do a day. That would give us some idea of our potential statistical power. It is likely that an online study would lack design, tight control, etc, but could make up for it in sheer statistical power. But maybe not: if a study is poorly designed, probably it would be a poor study no matter how large.

Like we sometimes say, experience may mean doing the same thing incorrectly for a lifetime.

Anyway, I admire your thoughts on this, and will look forward to what Andrea and Dr. Lyons have to say. Thanks for bringing this out.

We are minus 40 F here - could be worse.

--
Joseph A Worrall MD RDMS



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