Re: Yolk sac

From: Dr.Andrea Corda (acord@tin.it)
Wed Jan 27 14:31:33 1999


At Wed, 25 Nov 1998, Edward Lyons wrote: >
>JSS, JW and others
>The original paper we wrote on yolk sac size showed that a sac of 6 mm or
>more, internal diameter, could be abnormal for fetuses LESS than 10 weeks
>MA. For those over 10 weeks the sac can be normal at 6 mm or more. I too am
>unsure what prompted the concern in this case. Remember, our measurements
>were all done on endovaginal scans, not transabdominal ones.
>By the way, we measure the yolk sac in all cases under 10 weeks and find it
>to be a very useful sign. Is this the experience of others??
>
>E.A. Lyons MD
>Professor of Radiology/ Obstetrics and Gynecology
>Winnipeg
>-----Original Message-----
>From: James S Smeltzer MD <gaperina@mindspring.com>
>To: Multiple recipients of list <ultrasound@talk.obgyn.net>
>Date: Wednesday, November 25, 1998 6:06 AM
>Subject: Re: Yolk sac
>
>>Joseph,
>>
>>I closed my eyes & imagined this scenario & can not identify anything to
>>worry about. What am I missing? JSS
>>
>>At 07:00 PM 11/24/1998 -0600, you wrote:
>>>What do folks have to say about a pregnancy of 10w4d, normal appearing
>>>embryo/fetus, normal appearing placenta, no clinical problems, amnion
>almost
>>>completely fused, and a nice-looking, round thin-walled yolk sac of 5.9mm
>>>inner diameter? Although I could only see amnion where it was orthogonal
>to
>>>the sound beam, (I did not see any amnion near this yolk sac), the yolk
>sac
>>>did not appear at all compressed.
>>>
>>>The heart rate is 167, the embryo/fetus is active, the midgut has not
>>>returned to the abdomen.
>>>
>>>Joseph A Worrall MD RDMS
>>>

--
Sir,
I started measuring yolk sac size since 1993,when I heard a lecture you took in Las Vegas' ISUOG .I've found that a yolk sac size of 7 mm or more (outer-outer)before the end of the 7th week means almost certainly a chromosomal abnormality (if the pregnancy goes further on,of course;usually,it ends up with a spontaneous demise before the 10th week.)Also,the (normal) yolk sac has a growth rate in the very early pregnancy that is more or less the same of the embryo (i.e. :3 mm CRL,3 mm yolk and so on up to the normal size of more or less 5 mm ,when the embryo keeps on growing and the yolk sac stops.)So,if a find,say a yolk sac of 7 mm and a crl of 3mm in a viable embryo and the pregnancy goes on over the 12th week,I should perform a CVS or an amnio because almost certainly that fetus has some chromosomal anomaly.Almost certainly as well I'll be able to find an increased nuchal translucency,but this (the yolk sac)goes regardless of that and is a far more precocious sign.On the basis of yolk sac size I performed a series of kariotypes either on fresh abortive material,CVS or amniocentesis and ALL of them showed a chromosomal anomaly of different varieties.Up to now I've collected almost 50 cases thanks to a few colleagues who helped me.Do you agree with these findings?
As for hyperechoic yolk sac,I saw one today with a missed abortion.I saw the pregnancy two weeks ago and embryo was alive,5.2 mm yolk sac (normal appearance,round,even ),7 mm CRL,128 bpm.Today:16 mm CRL with what looked  like a hole in the thorax (?)(you should see the picture),5.3 hyperechoic yolk sac ,no EHR,no blood clots between chorion and decidua (early loss).Mother had flu 1 week ago.Could this be the result of a viral insult ? I'm quite convinced that the yolk sac could tell us a lot of stories about early pregnancy.Do you agree with me?Could we find out a way to collect our data in order to prove this hypothesis?
I'm sure this should not be a difficult task.
Please answer me
Regards,
Dr.Andrea Corda        acord@tin.it



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