Re: nuchal translucency

From: James S Smeltzer MD (gaperina@mindspring.com)
Tue Aug 4 07:34:51 1998


Hi Tania,

We are both right. The 30% you are talking about is 30% of the total incidence of Down's Syndrome that is detected by testing all with Maternal Age over 35.

The amniotic fluid cell culture, Chromosome count and Karyotype test itself will detect essentially all (with a small allowances for mosaic translocations and lab error) babies with Down's syndrome whose cells are tested. The newer, much faster and much cheaper fluorescent in situ hybridzation test will detect about 99Plus percent. This is not approved by the American Society of Human Genetics because it will put many of them out of business.

I hope this helps.

Jim Smeltzer (gaperina@mindspring.com)

At 07:17 PM 8/3/1998 -0500, you wrote: >In a message dated 03/08/98 12:11:47 GMT, gaperina@mindspring.com writes:
><< To: ultrasound@talk.obgyn.net (Multiple recipients of list)
>
> Hi OnebornJoy,
>
> Amnio detection rates are still the Gold standard ~100%. I do not think it
> is the equipment - as I have seen it equally well with high and low end
> with TVS. It is the sonographers and the sensitization.
>
> >>
>Are you saying that amnio detection rates for downs syndrome are 100%
>accurate.?
>I thought they only detected about 30% and that blood tests only 60%
>Blessings
>Tania
>




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