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Diabetes Insipidus and hydramniosFrom: Annibale Mazzocco (annigiu@tiscali.it)Sun Jul 20 03:41:33 2008
Hello: I have a 32-year-old patient, first pregnancy, at 23 weeks affected by central diabetes insipidus + hypothyroidism, now in treatment with minirin (3-4 puff /day) + eutirox 150 mg 7day. She is being treated by the endocrinological center of my hospital in Montebelluna –Treviso, Italy. In the first trimester she underwent a first trimester combined screening with a risk for T21 of 1/9297. I performed the anomaly scan at 20 w+5d and found normal morphology, fetal growth at 25’ centile , Amniotic Fluid at borderline (max fold 79 mm, AFI 180 mm). I suggested a new endocrinological consultation, also to gain time on the subject, and a new control after two week. At 23 +0 I found fetal growth at 10 centile (AC: 168, DBP: 53, HC: 292, F: 36, HL: 31), morphology still normal, hydramnios: AFI 238, max fold: 90. Uterine artery Doppler normal with medium IR 0,44, normal Doppler in UA. The endocrinologist didn’t change the therapy in any way. I didn’t find anything in Pub med about diabetes insipidus in pregnancy complicated with hydramnios and fetal grow restriction. Have you had cases like this? Do you have data about diabetes insipidus and hydramnios and fetal growth restriction, or on the other hand, do you think that these are casual concomitant factors ? Thank you so much Annibale Treviso Italy
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