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Re: Microcephaly - BBII analysisFrom: Terry J. DuBose (duboseterryj@uams.edu)Fri May 30 09:12:49 2003
Part of the problem is that the three dimensional head shapes relate to the volume (microcephaly vs macrocephaly). While some have advocated 3D measurements all the way back to Harold Jordaan of South Africa in the 1970's (Jordaan HVF; "The differential enlargement neurocranium in the fullterm fetus"; South African Medical J, 1976; 50:1978-1981. Jordan HVF and Dunn LJ; "A New Method of Evaluating Fetal Growth"; Obstet and Gynecol, 1977; 51:659-655. Jordaan HVF, Clark BW; "Prenatal determination of fetal brain and somatic weight by ultrasound"; Am J Obstet Gynecol, 1980; 136:54-59.), few have actually recognized that the vertical cranial diameter (VCD) of the fetal cranium is the most dynamic in the presence of molding and abnormal head shapes. If the head is normally shaped, then the BPD is really all that is needed. However, if the molding or head shape affects the VCD, as it most often does, then the transverse head circumference is simply not enough. In fact, I am of the opinion that the coronal head circumference is much more sensitive to these changes in head shape than is the transverse circumference. Compression of the BPD (dolichocephaly) is usually compensated by an exaggeration of the vertical axis rather than changes in the long axis or frontal-occipital; while compression at the top of the head reduces the VCD and compensates by exaggerating the BPD, resulting in a tendency toward brachycephaly. (see http://www.io.com/~dubose/3d.html also DuBose & Endres, Cohen; letters, JUM 2002 21:709-711 and related references.) While having two births with microcephaly does lead to a prognosis of genetic root causes, we should not forget fetal infections, which may also be associated with microcephaly... also remember craniosynostosis. Peace, Terry J DuBose, M.S. RDMS Little Rock, Arkansas USA ------------------------------------ ultrasound@obgyn.net writes: ------------------------------------ You must check or analysis your chromosomes, consult to genetist counsellor and perform ultrasound at first and second trimester. ------------------------------------ ~ Dr. Judi JE.SpOG =============================== Gatot Soebroto Central Army Hospital Veteran University School of Medicine Jakarta Pusat 10310. Tlp~~~~ : 021 - 34833234 Fax~~~ : 021 - 3927285 Email~ : [ mailto:judidsog@rad.net.id ]judidsog@rad.net.id
>----- Original Message ----- TO WHOM IT MAY CONCERN I WOULD LIKE TO KNOW IF IT IS POSSIBLE THAT U. CATCH OR EVEN SEE A SIGN OF A CHILD WITH MICECEPHALY E=WHILE A WOMEN IS PREGNET. I HAVE 3 BOYS, TWO OF WHOM ARE MICRCEPHOLIC AND HV=AVE SEIZURES, AND A NORMAL BOY THAT HAS A HIGH IQ AND EXTREMELY INTELLIGENT. I WOULD LIKE TO HAVE MORE KIDS BUT A LITTLE SCARED AND CONFUSED. SO CAN U GIVE ME YOUR SUGGESTIONS AND OPINION THANKS REEMA
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