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Nasal bones on lineFrom: Philippe Coquel (philippe.coquel@wanadoo.fr)Thu Nov 28 01:22:19 2002
the paper is on line Ph Coquel,MD http://www.jultrasoundmed.org/current.shtml Fetal Nose Bone Length A Marker for Down Syndrome in the Second Trimester Bryann Bromley, MD, Ellice Lieberman, MD, DrPH, Thomas D. Shipp, MD and Beryl R. Benacerraf, MD Departments of Obstetrics and Gynecology and Radiology, Massachusetts General Hospital, and Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts. Revised July 10, 2002. Revised manuscript accepted for publication August 1, 2002. Revision requested July 10, 2002. Revised manuscript accepted for publi-cation August 1, 2002. Address correspondence and reprint requests to Bryann Bromley, MD, Diagnostic Ultrasound Associates, 333 Longwood Ave, Boston, Massachusetts, 02115. Objective. To evaluate the significance of nasal bone length in relation to the detection of Down syndrome in the second trimester. Methods. We evaluated consecutive fetuses referred to our facility between 15 and 20 weeks' gestation for sonography and amniocentesis because of an increased risk of aneuploidy. A detailed structural survey, biometric measurements, and measurement of the nasal bone were obtained at the time of amniocentesis and subsequently compared with karyotype. The characteristics of the fetuses with Down syndrome were compared with those of the euploid fetuses. Results. A total of 239 fetuses were evaluated. Sixteen fetuses (7%) had Down syndrome, and 223 were euploid. In fetuses with Down syndrome, 6 (37%) of 16 did not have detectable nose bones, compared with 1 (0.5%) of 223 control fetuses, yielding a likelihood ratio of 83. Detectable nasal bones were seen in 10 fetuses with Down syndrome and 222 euploid fetuses. A receiver operating characteristic curve for the biparietal diameter-nasal bone length ratio showed that a value of 9 or greater detected 100% of fetuses with Down syndrome and 22% of euploid fetuses. If the ratio were 10 or greater, then 81% fetuses with Down syndrome and 11% of euploid fetuses would have been identified. If the ratio were 11 or greater, 69% of fetuses with Down syndrome would be identified, compared with 5% of euploid fetuses. Conclusions. The absence of a nasal bone is a powerful marker for Down syndrome. A short nasal bone is associated with an increased likelihood for fetal Down syndrome in a high-risk population. Key Words: aneuploidy, second trimester . fetal nose bone length . marker, fetal Down syndrome . midsagittal profile . sonography Abbreviations: BPD, biparietal diameter . DS, Down syndrome . NBL, nasal bone length . ROC, receiver operating characteristic
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