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Re: Calculation of Risk for Down From: Doc Gyn=?ISO-8859-1?B?6Q==?=co (jmbr@wanadoo.fr) Fri Feb 23 10:19:02 2001 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Ph Coquel: "Re: Calculation of Risk for Down" Previous message: zalel: "=?windows-1255?B?4fLw6envOiBDYWxjdWxhdGlvbiBvZiBSaXNrIGZvciBEb3du?" In reply to: Allen Worrall: "Calculation of Risk for Down" Next in thread: Ph Coquel: "Re: Calculation of Risk for Down" le 23/02/01 3:11, Allen Worrall a tapoté : > If we say the nuchal fold was normal (not yet 6 mm or greater): > hyperechoic bowel has a likelihood ratio of 5.5. If we consider her age > related a priori risk, it is ~ 1:302 at twenty weeks. Apply the > likelihood ratio for the hyperechoic bowel and her risk is now ~ 1:56, > clearly an indication for amniocentesis. Also if we use Dr. > Benacerraf's scoring system, age 35 and score 1, amniocentesis should be > recommended. > > Or should the 5.5 likelihood ratio be applied to her triple screen risk > of 1:7600, which would increase her risk to 1:1382,and thus > amniocentesis not indicated? Thanks for this interesting case. To alter her triple-screen risk you must be sure about statistical independance between the serum markers and the hyperechoic bowel marker. In my opinion, there is no study in this issue. So, you can't modified the triple screen risk. And the likelihood ratio could be apply to her age related risk. -- Regards, Dr J-M BRIDERON (MD) Gyn-Obs ECHOLIST : http://www.gyneweb.fr/echolist.htm Next message: Ph Coquel: "Re: Calculation of Risk for Down" Previous message: zalel: "=?windows-1255?B?4fLw6envOiBDYWxjdWxhdGlvbiBvZiBSaXNrIGZvciBEb3du?" In reply to: Allen Worrall: "Calculation of Risk for Down" Next in thread: Ph Coquel: "Re: Calculation of Risk for Down"

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