Re: R: Re: Alpha Thalassemia
From: Dr Fazeel uz Zaman (fazeel@atd.hazara.net.pk)
Tue Jan 16 09:08:27 2001
Dear Sir,
Please tell us about the "X-linked SCID", full detail.....starting from what is
SCID?
dr. Fazeel
The-Hung Bui wrote:
> At 06:59 2001-01-16 -0600, you wrote:
> >You're right!
> >I live in Sardinia and we have to face daily these problems .We had endemic
> >malaria until the end of the WWII when the US came and wipe it out with DDT.
> >We also tried recently to put donor bone marrow cells via cordocentesis to
> >an affected fetus but the results were somewhat confusing-maybe an
> >incomplete graft versus host reaction with both blood cells on the blood of
> >the newborn.
> >Andrea Corda.
>
> Dr Corda,
> I would be interested in knowing more about your case. I suppose it was a
> case of beta-thal. When (which year) and at what gestational age was the IU
> transplant (IUT) performed? Since you mentioned cordocentesis, I guess it
> was in the midtrimester. Was the donor one of the parents? Do you mean you
> have evidence of microchimerism at birth?
>
> I am part of the ENFET concerted action (European Network for Fetal
> Transplantation) that is supported by the European Commission and the ENFET
> programme is just starting from 1 Jan 2001 for 4 years. We would very much
> be interested in knowing more about your patient. As you may know our group
> has performed 4 unsuccessful cases of IUTs for both alpha- and beta-thal (1
> resp. 3 cases, incl 1 for sickle cell anemia) from referred patients. This
> has been published a few years ago. We have on record one successful case
> for X-linked SCID, now nearly two year-old. If you wish you could get in
> touch with me directly.
>
> *****************************************************************
> The-Hung Bui, M.D.
> Senior Consultant
> Director, Fetal Diagnosis Programme
> Department of Molecular Medicine
> Clinical Genetics Unit
> Karolinska Hospital
> S-171 76 Stockholm, Sweden
>
> phone: +46 8 517 74989 or 517 72472 (secretary)
> fax: +46 8 32 77 34
> E-mail: The-Hung.Bui@ks.se
