Re: R: Re: Alpha Thalassemia

From: The-Hung Bui (The-Hung.Bui@ks.se)
Tue Jan 16 08:48:55 2001


>From DuboseTerryJ@uams.edu Tue Jan 16 09:48:54 2001
Received: from exchange1.uams.edu (exchange1.uams.edu [144.30.1.148]) by mail.medispecialty.com (8.9.3/8.9.3) with ESMTP id JAA09632 for <ultrasound@obgyn.net>; Tue, 16 Jan 2001 09:48:54 -0600 From: DuboseTerryJ@uams.edu Received: by exchange1.uams.edu with Internet Mail Service (5.5.2653.19) id <YM3Z6CYR>; Tue, 16 Jan 2001 09:48:54 -0600 Message-ID: <FA16403E0560D211B453006097CEBBBE06F90BC7@exchange2.uams.edu> To: ultrasound@obgyn.net, ultrasound@forum.obgyn.net Subject: Re: R: Re: Alpha Thalassemia Date: Tue, 16 Jan 2001 09:48:51 -0600 MIME-Version: 1.0 X-Mailer: Internet Mail Service (5.5.2653.19) Content-Type: text/plain; charset="iso-8859-1"

While I can understand the impulse to "get in touch with me directly" in some cases. I would hope that we could continue the discussions in this open forum... we can all learn from this experience.

Peace, Terry J. DuBose, M.S., RDMS, Assistant Professor Director, Diagnostic Medical Sonography Program CHRP, University of Arkansas for Medical Sciences Little Rock, Arkansas, USA 501-686-6510 http://www.io.com/~dubose/ http://www.uams.edu/CHRP/dmshome.htm http://www.obgyn.net/us/panel/panel.htm

-----Original Message----- From: The-Hung Bui [mailto:The-Hung.Bui@ks.se] Sent: Tuesday, January 16, 2001 8:27 AM To: Multiple recipients of list ULTRASOUND Subject: Re: R: Re: Alpha Thalassemia

At 06:59 2001-01-16 -0600, you wrote: >You're right!
>I live in Sardinia and we have to face daily these problems .We had endemic
>malaria until the end of the WWII when the US came and wipe it out with
DDT. >We also tried recently to put donor bone marrow cells via cordocentesis to
>an affected fetus but the results were somewhat confusing-maybe an
>incomplete graft versus host reaction with both blood cells on the blood of
>the newborn.
>Andrea Corda.

Dr Corda, I would be interested in knowing more about your case. I suppose it was a case of beta-thal. When (which year) and at what gestational age was the IU transplant (IUT) performed? Since you mentioned cordocentesis, I guess it was in the midtrimester. Was the donor one of the parents? Do you mean you have evidence of microchimerism at birth?

I am part of the ENFET concerted action (European Network for Fetal Transplantation) that is supported by the European Commission and the ENFET programme is just starting from 1 Jan 2001 for 4 years. We would very much be interested in knowing more about your patient. As you may know our group has performed 4 unsuccessful cases of IUTs for both alpha- and beta-thal (1 resp. 3 cases, incl 1 for sickle cell anemia) from referred patients. This has been published a few years ago. We have on record one successful case for X-linked SCID, now nearly two year-old. If you wish you could get in touch with me directly.

***************************************************************** The-Hung Bui, M.D. Senior Consultant

--
Director, Fetal Diagnosis Programme
Department of Molecular Medicine
Clinical Genetics Unit
Karolinska Hospital
S-171 76 Stockholm, Sweden

phone: +46 8 517 74989 or 517 72472 (secretary) fax: +46 8 32 77 34 E-mail: The-Hung.Bui@ks.se ******************************************************************




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