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Re: R: Re: Alpha ThalassemiaFrom: The-Hung Bui (The-Hung.Bui@ks.se)Tue Jan 16 07:25:47 2001
At 06:59 2001-01-16 -0600, you wrote: >You're right! >I live in Sardinia and we have to face daily these problems .We had endemic >malaria until the end of the WWII when the US came and wipe it out with DDT. >We also tried recently to put donor bone marrow cells via cordocentesis to >an affected fetus but the results were somewhat confusing-maybe an >incomplete graft versus host reaction with both blood cells on the blood of >the newborn. >Andrea Corda. Dr Corda, I would be interested in knowing more about your case. I suppose it was a case of beta-thal. When (which year) and at what gestational age was the IU transplant (IUT) performed? Since you mentioned cordocentesis, I guess it was in the midtrimester. Was the donor one of the parents? Do you mean you have evidence of microchimerism at birth? I am part of the ENFET concerted action (European Network for Fetal Transplantation) that is supported by the European Commission and the ENFET programme is just starting from 1 Jan 2001 for 4 years. We would very much be interested in knowing more about your patient. As you may know our group has performed 4 unsuccessful cases of IUTs for both alpha- and beta-thal (1 resp. 3 cases, incl 1 for sickle cell anemia) from referred patients. This has been published a few years ago. We have on record one successful case for X-linked SCID, now nearly two year-old. If you wish you could get in touch with me directly. ***************************************************************** The-Hung Bui, M.D. Senior Consultant -- Director, Fetal Diagnosis Programme Department of Molecular Medicine Clinical Genetics Unit Karolinska Hospital S-171 76 Stockholm, Sweden
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