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Re: Attn Dr Marchbein Re: progesterone & maintaining pregnancy

From: Harvey S. Marchbein, M.D. (anonymous@obgyn.net)
Mon, 27 Dec 1999 19:28:21 -0600 (CST)


At Sun, 26 Dec 1999, Jas wrote: >
>Hi Dr Marchbien
>
>Now I am intigued by your reply and explaination of progesterone's role
>in pg later on. If I understand correctly what you are saying about
>progesterone then those of us who deliver preterm may have a sudden
>premature drop of our progesterone level too early?

One possibility but then we have to figure out why. Subclinical infection? Less progesterone receptors (not less progesterone but lower ability to respond to it since receptors help get the work done) in the uterus and if so, why? Let's not leave out incompetent cervix (unrelated to progesterone), multiple births (posibly related to stretching of the uterus and "hitting it's limits") and others that will come to me later, I'm sure.

>What I was wondering
>is there a certain range or progesterone level number for later pg?

I've never seen it but I'm sure there's an article somewhere. The problem is even if you know the amounts, we have no way to change it in 1999/2000 after the first trimester.

>Can
>something like a level in later pg be checked to see if it is fallling
>too early that would alert one to the possiblitly of preterm delivery?

Good question. Wish the answer was known.

>In my last pg I used progesterone supplements early on until week 11.
>Week 12 I had a large abruption of the placenta and bleeding.
>Immediately I was hospitalized for one week and given progesterone
>injections daily 2x a day. After a week progesterone was discontinued
>and the placenta stabilized. I did carry the baby to 34 weeks
>completion. I just wonder if my progesterone level is wacky in pg and
>it causes me all sorts of weird stuf with bleeding, uterine
>irritability, preterm delivery etc to occur. My Dr teases I think too
>much but now I am really wanting to know about progesterone testing in
>later pg. Any thoughts?
>

You don't think too much. We probably know too little but hope springs eternal for the future. ;-)

--
Harvey S. Marchbein, M.D. FACOG, FACS
Great Neck, New York

**Note: Opinions expressed here are for educational purposes only and, as such, do not constitute a physician-patient relationship. This information is not intended to supplant the need for you to consult with your physician prior to choosing therapeutic options and/or interventions.

**Private emails cannot be entertained due to time constraints, consequently no private emails will receive a response.

**Thank you for your understanding ;-)




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