Attn Dr Marchbein Re: progesterone & maintaining pregnancy

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Now I am intigued by your reply and explaination of progesterone's role in pg later on. If I understand correctly what you are saying about progesterone then those of us who deliver preterm may have a sudden premature drop of our progesterone level too early? What I was wondering is there a certain range or progesterone level number for later pg? Can something like a level in later pg be checked to see if it is fallling too early that would alert one to the possiblitly of preterm delivery? In my last pg I used progesterone supplements early on until week 11. Week 12 I had a large abruption of the placenta and bleeding. Immediately I was hospitalized for one week and given progesterone injections daily 2x a day. After a week progesterone was discontinued and the placenta stabilized. I did carry the baby to 34 weeks completion. I just wonder if my progesterone level is wacky in pg and it causes me all sorts of weird stuf with bleeding, uterine irritability, preterm delivery etc to occur. My Dr teases I think too much but now I am really wanting to know about progesterone testing in later pg. Any thoughts?

At Sun, 26 Dec 1999, Harvey S. Marchbein, M.D. wrote: >
>At Sun, 26 Dec 1999, JHopkins wrote:
>>
>>Can anyone give the exact role of progesterone in maintaining a
>>pregnancy?
>
>Throughout the entire pregnancy, it prevents delivery. In early
>pregnancy, it helps maintain the the appropriate level necessary to
>prevent miscarriages solely on the basis of low prgesterone in some
>patients. Progesterone plays a role with basically "keeping the uterus
>quiet". Proigesterone is initially produced by the corpus luteum cyst,
>the cyst produced by the recent ovulation. By 8-10 weeks the placenta
>starts to take over and produces more progesterone than can be given
>either orally or by injection by 12-14 weeks.
>
>In late pregnancy, progesterone drops and this is felt to be one of the
>causes of labor. Dropping progesterone destabilizes the lysosomal
>packets involved with prostaglandin release, thereby allowing
>prostaglandin to be released. This promotes rupturing of membranes and
>contractions. (This is the most accepted "model" of how labor starts
>that I am aware of)
>
>>What is the role of it and how long is it vital to the
>>developing fetus?
>
>Answered above.
>
>>Are there any hormonal disorders that will prevent the
>>production of progesterone during a pregancy?
>
>Luteal phase defect and supplementation with progesterone will help for
>up to 3 months. After that, the placenta is on its own.
>
>>Any information will be
>>greatly appreciated. Thank you.
>
>--
>Harvey S. Marchbein, M.D. FACOG, FACS
>Great Neck, New York
>
>**Note: Opinions expressed here are for educational purposes only
>and, as such, do not constitute a physician-patient relationship.
>This information is not intended to supplant the need for you to
>consult with your physician prior to choosing therapeutic options
>and/or interventions.
>
>**Private emails cannot be entertained due to time constraints,
>consequently no private emails will receive a response.
>
>**Thank you for your understanding ;-)
>

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