PREGNANCY-BIRTH Messages for December, 1999: Re: progesterone & maintaining pregnancy

Re: progesterone & maintaining pregnancy

From: Harvey S. Marchbein, M.D. (anonymous@obgyn.net)
Sun, 26 Dec 1999 21:36:59 -0600 (CST)

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Reply: Jas: "Attn Dr Marchbein Re: progesterone & maintaining pregnancy"

At Sun, 26 Dec 1999, JHopkins wrote: >
>Can anyone give the exact role of progesterone in maintaining a
>pregnancy?

Throughout the entire pregnancy, it prevents delivery. In early pregnancy, it helps maintain the the appropriate level necessary to prevent miscarriages solely on the basis of low prgesterone in some patients. Progesterone plays a role with basically "keeping the uterus quiet". Proigesterone is initially produced by the corpus luteum cyst, the cyst produced by the recent ovulation. By 8-10 weeks the placenta starts to take over and produces more progesterone than can be given either orally or by injection by 12-14 weeks.

In late pregnancy, progesterone drops and this is felt to be one of the causes of labor. Dropping progesterone destabilizes the lysosomal packets involved with prostaglandin release, thereby allowing prostaglandin to be released. This promotes rupturing of membranes and contractions. (This is the most accepted "model" of how labor starts that I am aware of)

>What is the role of it and how long is it vital to the
>developing fetus?

Answered above.

>Are there any hormonal disorders that will prevent the
>production of progesterone during a pregancy?

Luteal phase defect and supplementation with progesterone will help for up to 3 months. After that, the placenta is on its own.

>Any information will be
>greatly appreciated. Thank you.

--
Harvey S. Marchbein, M.D. FACOG, FACS
Great Neck, New York

**Note:  Opinions expressed here are for educational purposes only
and, as such, do not constitute a physician-patient relationship.
This information is not intended to supplant the need for you to
consult with your physician prior to choosing therapeutic options
and/or interventions.

**Private emails cannot be entertained due to time constraints,
consequently no private emails will receive a response.

**Thank you for your understanding ;-)

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