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Re: Progesterone during pregnancy?From: anonymous@obgyn.netFri, 10 Sep 1999 00:23:56 -0500 (CDT)
At Mon, 22 Mar 1999, Tina wrote: > >Hello >I am not a medical doctor but I have a Ph.D. in biochemistry. I am >currently in my 31st week. During my first week, I spotted and when >checked, discovered that my progesterone was borderline. My OB >prescribed Protmetrium for me (I can't remember the dose but it amounted >to 2 tablets/day). I read the product insert and also was scared but >the same line (not recommended for pregnancy...). I called Solvay >Pharmaceuticals who is the producer of Prometrium (if I recall >correctly). Anyway, I spoke with one of their Ph.D.s who worked on >Prometrium. She told me there have been isolated cases of children born >with birth defects whose mothers had used Prometrium. The birth defects >were one case of cleft pallate (sp?), a couple of cases of heart >problems. However, there was no evidence to indicate these problems >were directly caused by the progesterone and were merely coincidental. >However, because they occurred and these mothers had taken Prometrium, >they were required to use this disclaimer in the product insert. She >went on to tell me the statistics (although I can't remember them) on >the number of "normal" babies born to mothers taking prometrium. To me, >there was a greater risk of losing the baby than having birth defects >caused by supplemental progesterone. I have had 2 u/s and my babies >heart looks perfect. Additionally, I my best friend was on progesterone >suppositories with her second child (after miscarrying her first - which >was attributed to progesterone deficiency). Her now 4 year old daughter >is very intelligent and healthy. I know, however, that many OBs state >that their is no proven relationship between supplementing with >progesterone and not-miscarrying. Incidentally, I had swithched OBs >shortly after initiating the Prometrium. The new OB told me that as far >as he was concered my progesterone was not too low but that if taking it >eased my mind then to take it as there was no risk to the baby. I ended >up taking only 1 pill per day which may have been physically >inconsequential but mentally reassuring at the time. Sorry this is so >long. > >Tina > >At Sun, 21 Mar 1999, Monica wrote: >> >>I was wondering how safe progesterone (Prometrium specifically) is to >>use during pregnancy? I know a woman whose daughter was born with heart >>defects attributed to the use of prosterone during her pregnancy. The >>insert in the box specifically says "Do not use Prometrium if you are >>pregnant or nursing." Why would my OB prescribe this for my pregnancy if >>it is unsafe to use while pregnant? This is my ninth pregnancy, and I >>have two children. My last miscarriage was in October 98, at 10 weeks >>(all my losses were 6-7 weeks developed). I am extremely frightened of >>losing another child, so I accepted the progesterone prescription from >>my doctor, but I am also afraid of causing the baby and harm. >>How long is progesterone usually used in a pregnancy? The package insert >>says that if you stop taking it you will shed the lining of your uterus. >>Could it cause a miscarriage if I stop taking it? >>I have also learned that natural progesterone is less harmful than >>synthetic progesterone. Is "Prometrium" a natural or synthetic >>progesterone supplement? >>I understand that it is almost impossible to diagnose problems online, >>but I would appreciate any statistics and information you can give me. >> >>Thank you in advance for your help. >> >>-- >>Monica >> >-- >
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