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Aging & M/C & Genetic Defects

From: Ann-Marie (anonymous@obgyn.net)
Sun, 13 Jun 1999 10:55:05 -0500 (CDT)


Background: I am currently 39 years old. My first pregnancy ended in a missed abortion at 8 weeks. A fetal heartbeat was never detected. I got pregnant right before we started actively trying. I was 36 years old.

My second pregnancy ended in a healthy baby boy who is now almost two years old. I got pregnant at first attempt. I was 36 years old.

My third pregnancy just ended at 14 weeks 1 day. Tests have determined that the baby had a genetic abnormality called Trisomy 18. I got pregnant at first attempt. I was 38 years old at time of conception.

I understand that Trisomy 18 is much rarer than Trisomy 21 I have seen on the'net various statistics saying that the risk of having a pregnancy like this was anywhere from 1 in 378 to 1 in 2400 at age 38. I understand that the risk of having a T21 child is much higher something like 1 in 100 at my now age of 39.

I am VERY worried that because I have had two m/c that there is something wrong with my eggs due to age. Yet I understand that the FSH test is only if you are having difficult conceiving...

Any advice, comments would be welcomed as I so long to have a second child yet am terrified of having another genetic problem. DH and I have had genetic counseling and everything appears to be fine.

Thanks, Ann-Marie

P.S. I am currently waiting out two menstrual cycles to begin trying and am also terrifed that due to my age 39 that this won't happen as everything that I read on the net tells how fertility declines each month over 35 so I am also VERY anxious about waiting two WHOLE cycles to try again despite past history of no problems conceiving. So my second question is is it really necessary to wait to whole cycles, isn't this risky given my age?




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