PREGNANCY-BIRTH Messages for March, 1999: Re: chromosomal rearrangement & hereditary miscarriages

Re: chromosomal rearrangement & hereditary miscarriages

From: Jas (anonymous@obgyn.net)
Tue, 2 Mar 1999 12:10:59 -0600 (CST)

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In reply to: Mary: "chromosomal rearrangement & hereditary miscarriages"

I had the expensive testing you are referring too. It was a chromosome kariotype blood test done on both my husband and myself. We had it done after one miscarriage even though I had carried a baby to term before the miscarriage. You sound like a good candidate for having it done with your history as it may give you some insight on what may contribute to your loss. In our case they where looking for what they call a balanced translocation of chromosomes. This is a rearrangement which can contribute to a miscarriage early on and some could even in rare situations can lead to a loss after the first trimester. It sounds to me like this is what they may be looking for in your case. Balanced translocations can vary from severe to mild. In our case we found that I carried a balanced translocation that was mild but nevertheless was most likely the cause for the miscarriage. The good news is I have 2 healthy babies despite the arrangement and they suffer no physical consequences that we know of. The interesting thing is if I were to have both my children kariotyped they may or may not carry my translocation. These translocation can skip generations or different members of the family. What we do know it came down from my side of the family since I am the carrier and not my husband.

Don't despair if you have the testing and something is found. Unless it is a severe chromosome problem your chances of having a miscarriage is luck of the draw. In my opinion I say go for the testing if they offer it to you. Ours was $500 a piece to be checked. Our children have not been tested but instead will be informed when they are adults in case it may affect their fertility.

Here is a link to my little wonders. I was advised to do CVS with Katherine and I declined and took my chances.

http://w3.gwis.com/~jsmith/kids/

At Tue, 2 Mar 1999, Mary wrote: >
>Hello. My first pregnancy ended due to a blighted ovum a month ago.
>Yesterday when I went to see my OB for a post-partum, she said that,
>despite the random nature of blighted ovums and the fact that 25% of
>first pregnancies end in miscarriage, I may want to think about a
>(expensive) test for chromosomal rearrangement (between my husband and
>me) which would prevent me from carrying our pregnancy to term. She
>mentioned the test because yesterday I noted my family history (my
>mother had three miscarriages and my mother-in-law had two
>miscarriages), but said she would probably only order the test after two
>or three miscarriages. (My OB is a university physician and may be more
>likely to mention the test since her research pertains to chromosomes.)
>
>So has anyone ever heard of chromosomal rearrangement or what it means
>in terms of my odds of carrying our pregnancy to term? Is the tendency
>to miscarry passed down from one generation to the next?
>
>Thank you.

Next message: Christopher: "Re: Diastasis recti"
Previous message: Christine: "Diastasis recti"
In reply to: Mary: "chromosomal rearrangement & hereditary miscarriages"

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