CMV IgG and IgM

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Wife's age: 30 years (may help in evaluating the probability of a first vs subsequent infections)

IgG and IgM titers:

DATE IgG IgM unit 05-Oct-98 37 20 E.U./ml 09-Dec-98 35 13 E.U./ml 17-Dec-98 29 10 E.U./ml 08-Feb-99 23.5 5 E.U./ml

Thresholds ( they depends on the test method so I include them for reference): IgG is considered negative below 18 and positive above 23 IgM is considered negative below 30 and positive above 40

The pregnancy started around 20-Aug-98.

Here are the questions:

1. If you look at the titers you can extrapolate a descending curve: does it mean that my wife has been recently exposed to the virus?

2. Can you identify the exact period of time when the virus was active and understand if it happened before or after the 20-Aug-98 ?

3. Is is possible to distinguish between a first exposure to the virus and a second one? I think that we should not see the IgG positiveness the first time you get in contact with the CMV.Only IgM should raise(?)

Thank you very much for all the info and help you can give us.

Marco

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