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Re: depakote use in pregnancy

From: James Connerth MD (anonymous@obgyn.net)
Wed, 20 Jan 1999 12:04:41 -0600 (CST)


At Sun, 17 Jan 1999, adriane wrote: >
>I have a history of grand mal seizures and have been
>seizure free on depakote for 6 years. I am now considering
>getting pregnant and would like more information on
>depakote use in pregnancy. I am on 4mg of folic acid and
>have been informed by neurologist that there is a very
>high risk that if I were to come off the medicine the
>seizures would return. Any information would be much
>appreciated.

Many new studies suggest that if seizure free for 2-3 years,can try coming off meds under neurologist's supervision.Also depends on initial cause of seizures.Data suggests valproic acid is a teratogen--some new work casting little doubt on this.Would rec. switching to another drug for pregnancy;discuss this with your OB.




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