Re: folic acid... question for doc

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At Thu, 31 Jul 2003, Marie wrote: >
>At Thu, 31 Jul 2003, steph wrote:
>
>I have had a baby with a neural tube defect in the past so the doctor
>put me on 4 mg. of folic acid in preparation for the next pregnancy.
>Since my precare conceive pre-conception vitamin has already 1 mg. of
>folic acid, is this too much? I'm thinking that he forgot that the
>vitamin already has some.
>
>--
>steph
>
>Dear Steph,
>5mg is normal for high-risk(history/NTD)& deficient(Tegretol causes
>deficiency) Link: http://www.vh.org/adult/provider/obgyn/folicacid/
>
>"The largest randomized prospective trial reported in Great Britain in
>1991 involved 1,817 women who had a child with a NTD. One group
>received 4mg folic acid daily; one group received seven other vitamins;
>one group received both folic acid and seven vitamins; and a fourth
>group received only iron and calcium. The supplementation started at
>least four weeks before conception and continued until 12weeks from the
>last menstrual period.
>
>The study revealed a 72% reduction in affected pregnancies for a
>relative risk of 0.28 in both of the folic acid groups and no reduction
>in the other two groups. This led the CDC in August 1991 to recommend
>that women who have had one child with NTD take 4mg folic acid per day
>at least four weeks before conception and through the first three months
>of pregnancy. In 1993, the Clinical Teratology Committee of the
>Canadian College of Medical Geneticists recommended a minimum dosage of
>folic acid of 0.8 mg/day, but not exceeding 5mg/day, for women who are
>at increased risk of having offspring with NTD.(This covers your
>situation, some more recent studies have shown higher levels safer, be
>sure to have your B12 levels checked, supplements are absorbed easier
>than diatary folate) I hope this helps,
>Marie
>

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