PREGNANCY-BIRTH Messages for July, 2003: Re: cholestasis' risk to babies?

Re: cholestasis' risk to babies?

From: Marie

anonymous@obgyn.net

Wed, 30 Jul 2003 09:03:01 -0500 (CDT)

I suffered from cholestasis during both of my pregnancies, and only discovered this after my second delivery. My second child died 2months ago from vitamin-k deficiency bleeding. I'm now finding so much info that i'd never been told, and am in the process of making pamphlets for vit-K and cholestasis. What i'm trying to figure out is: 1.Is there a risk for the newborn to contract cholestasis from the mother? In several studies on VKDB I've found that many of the newborns had cholestasis of some sort. 2.Where else would it have been derived from? 3.If the newborns did have cholestasis, were they likely to have suffered in a similar way, itchy bodies?

I am really feeling desparate for answers to these 3 questions and feel very thankful for any answers.

Thank you, Kirry Nelson

Dear Kirry, I'm sorry for your loss. Have you email-address for information,not enough room here? My daughter-in-law had ICP in her2pregnancies undiagnosed during 1st and diagnosed@35weeks 2nd, she was itching since week15 and off work on disability. Second baby safely delivered@37weeks/9.8lbs! @2months she weighed-14.4lbs! ICP's under-diagnosed and very misunderstood.

Babies don't contract cholestasis per-se, but are adversly affected by the build-up of "sluge" limiting oxygen, vitamins-E,D,K,A malabsorbtion may affect liver-function etc. Vitamin-E-deficiency=peripheral neuropathy&possibly hemolysis. Vitamin-D-deficiency=osteomalacia&rickets. Vitamin-K-deficiency=coagulopathy&possibly reduced brain development&hemmorage. Vitamin-A-deficiency does't result in clinical disease in cholestasis. This is why it's necessary to deliver early to prevent fetal distress and/or stillbirth. There're few studies of postpartum consequences, ICP's effects are thought limited to pregnancy.

Both ICP and Rx-Cholestyramine(frequently Rx for ICP)cause/excaberate vitamin-deficiency, however,Ursodeoxycholic-acid is effective reducing pruritus and abnormalities in liver-function-tests and now the preferred treatment if Dx early enough, however both mother and child will need V-K treatment.

-- Grand-daughters@top height/weight charts and redish-skin coloration suggesting lingering hypersensitivity. I believe there may be differences in potential future effects depending on the sex of the child, due to the estrogen content of the "sluge" and estrogen birth-control-pills are contraindicated.

I hope this answers some of your questions,

Marie

Here are some links: http://www.itchymoms.com/ http://www.aafp.org/afp/990215ap/829.html http://www.ikp.unibe.ch/lab2/ICP.html http://bmj.com/cgi/content/full/309/6964/1243 http://bmj.com/cgi/content/full/324/7330/123 http://www.angelfire.com/sc/weltin/icpoverview.htm http://author.emedicine.com/PED/topic383.htm http://www.medigraphic.com/pdfs/hepato/ah-2002/ah021f.pdf Effects of meconium staining and prenatal anoxia. http://gucfm.georgetown.edu/welchjj/netscut/neonatology/perinatal_asphyxia.html Effects beyond fetal death of lack of oxygen related to ICP. http://www.neonatology.org/syllabus/perinatal.asphyxia.htm http://www.sickkids.on.ca/FrontiersinFetalHealth/FFHApril2000.asp#Germain http://www.wmpi.net/reviews/oc/oc_intro.htm (click onto each section)

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