Re: uti and Septra DS

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I am 20 weeks, and was just diagnosed with a uti. On Monday, the dipstick just came up with a trace of protein, but today they said I have a uti with the microorganism, Proteus Mirabilis. I had been on Macrobid 1x a day for prevention. However, this time, Macrobid will not work, because they said the infection is resistant to it.

So, the nurse prescribed Septra DS. Is this safe in the second trimester? I am to take it for 10 days.

Is there a safer alternative for Proteus?

I realize that an untreated uti is very dangerous, but am I also putting my baby's life at risk with Septra?

Could it cause birth defects or stillbirth?

Thank you for your help.

Dear Anon, Septra is a "Sulfa" drug and if you have had an allergic reaction to any medication, especially Sulfa drugs, antibiotics, you need to use caution taking this medication as it may cause serious adverse drug reactions or anemia. The risk to the fetus in the 1st trimester is related to folate metabolism and NTD, however, folate is needed for other processes as well so there could be a need to monitor folate levels at any time. It is cat C there are few findings of congenital anomalies however, since SEPTRA may interfere with folic acid metabolism, it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus and is contraindicated in patients with a known hypersensitivity to sulfonamides and in patients with documented megaloblastic anemia due to folate deficiency, it is also contraindicated in pregnant patients at term and in nursing mothers, because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus. Sulfamethoxazole; is contraindicated in pediatric patients less than 2 months of age. Of the three trimesters, there is less risk during the second, so it depends on what your individual history is with this kind of medication. Marie

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