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Re: Birth defects and methotrexate - 50mg/m2

From: anonymous@obgyn.net
Tue, 13 May 2003 00:15:28 -0500 (CDT)


At Mon, 12 May 2003, Peter wrote: >
>My wife was given 50mg/m2 dose of methotrexate to abort ectopic pregnancy.
>It turned out that the pregnancy is not ectopic, and we're now waiting to
>see if our baby will survive. He/she was alive yesterday after three
>days of methotrexate.
>My question is: If the baby survives, what are a chances that it will not
>have major birth defects ?

Peter, I'm sorry about your current predicament -- it sounds very scary. I looked into this myself, having had an ectopic that was treated with methotrexate, and what I learned was not encouraging. It is NOT considered safe for a fetus to be exposed to methotrexate. Before they'll give you the injection, many clinics will even require that you sign an agreement promising to have a D&C if an intrauterine pregnancy persists. This is because of the danger of significant fetal deformities. If you go to http://www.pubmed.com/ and enter search terms like methotrexate, ectopic, and fetal anomalies, you'll find some frightening case studies.

I'm sorry to sound so dire when you must already be worried sick. It's hard to find straightforward information out there sometimes, so I wanted to be frank. I hope you and your wife are holding up okay -- I wish you both a swift recovery.




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