PREGNANCY-BIRTH Messages for March, 2002: Re: 2 m/c in a row for NORMAL couple: bad luck or sth else?

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Re: 2 m/c in a row for NORMAL couple: bad luck or sth else?

From: anonymous (anonymous@obgyn.net)
Mon, 18 Mar 2002 12:30:52 -0600 (CST)

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Hi not a doctor, but am in similar situation. I have 3 children all conceived easily and with no miscarriages ever. Trying for our 4th, we have had 3 losses in a row in 10 months (1 later loss, and 2 chemical prengancies). My doctor went ahead and referred me to RE and we did all testing and their only answer at this point is "bad luck" as everything is coming back normal. I am 38, so that alone could account for it. My understanding is that while most miscarriages are due to chromosomal abnormalities, only a very small percentage of those chromosomal errors are due to problems in the parents. The other kinds of chromosomal errors that most commony result in early miscarriage are random errors that occur at fertilization and which have nothing to do with the genetic makeup of the parents. I know it i maddening not to have an answer. Good luck.

At Mon, 18 Mar 2002, anonymous@obgyn.net wrote: >
>One Dr. on this forum said that 1 out of 100 Normal couple will have 2
>m/c in a row.
>1. Then how common is that for a NORMAL couple to have two m/c in a row
>due to chromosomal abnormality?
>We had 2 first trimester m/c at the age of 30 (DH 31) with the second
>being trisomy 22 and the first unknown and DH and I are normal
>genetically.
>2. I don't know whether the first one was due to a chromosomal problem
>also or not but if it is (since most early m/c is caused by chromosomal
>issue) then why it could happen twice in a row since both of us do not
>have numerical or structural chromosome problem from the bloodwork?
>3. We both tested for everything which would cause m/c and both normal.
>If the first one was not due to chromosome problem then what else could
>cause the abnormal development of the embryo?
>4. Or did we just have back luck?
>5. And how common is that chromosome defect is in the ovary or testes
>if not from the bloodwork?
>Can you please shed some light on this? Thanks a lot!

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