PREGNANCY-BIRTH Messages for March, 2002: Re: 3rd miscarriage on the way

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Re: 3rd miscarriage on the way - do I have hope?

From: R. Daniel Braun, MD (anonymous@obgyn.net)
Thu, 14 Mar 2002 15:18:08 -0600 (CST)

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In reply to: Jenny: "3rd miscarriage on the way - do I have hope?"

At Thu, 14 Mar 2002, Jenny wrote: >
>I tested positive for p/g this Tuesday at 4wk2day (lmp 2/11): beta HCG
>is 472 and progestorne is more than 40. But yesterday evening all of a
>sudden my p/g symptoms were gone: nipples and breasts are no longer
>sore; mild nausea also disappeared. I just don't feel pregnant. I had
>another bloodwork done this morning and am still waiting for the result;
>but I trust my six sense. With my last m/c, h/b was seen when I had p/g
>symptoms and when those symptoms suddenly disappeared I felt sth was
>wrong and went in for a check and the h/b was no longer found at 7/8 wk
>and later they found it was due to trisomy 22. The first m/c was at 5
>wk and no reason found. Blookwork for me and DH to test for genetic
>problem: normal; I do not have LPD, no ANA, ACA, and lupus-AC; HSG
>normal; day 3 hormorne all normal. Then what is wrong with me or DH?
>Why can't I keep the pregnancy? If the second m/c was an accident then
>what's the reason for the first and this one? The embryo didn't develop
>well? If so why the abnormal development happened twice since my eggs
>are still good (day3 fsh 4.8)? Or like what I was told the chromosomal
>abnormality may exist in the ovary or DH's testes? But I know it is VERY
>rare. If assume this is our problem, does that mean that every single
>egg in the ovary or every single sperm in the testes has chromosome
>problem and we do not have any hope?
>I've been living in hell for the past 2 years. Please give me a
>guidance or direction I can follow to the fulfillment of baby dream!
>Thank you for the help!

One of every ten pregnancies ends up as a first trimester miscarriage. that means that 1 of every 100 NORMAL women will have 2 miscarriages in a row. Most Hyns don't do any evaluation until after the third mc in a row. Trisomy in th efetus is the most common cause found. The chromosomal problem occurs as the egg or the sperm are undergoing meiosis(reduction division) where it sheds 23 chromosomes so that when the egg and sperm join, there will only be 46 chromosomes.

--
R.Daniel Braun, MD  FACOG   FOG
**Note:  Opinions expressed here are for educational purposes only
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