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hyperemisis - any new treatments? and response to 'mehs' re: depression

From: Anonymous (anonymous@obgyn.net)
Tue, 19 Feb 2002 23:03:23 -0600 (CST)

Two things: (1) I had completely debilitating hyperemisis with my pregnancy 4-5 years ago. Apparently, it led to preterm labor as my son was born 6 weeks early. My treatment was mostly IV therapy, numerous hospital stays, and many drugs and injections e.g. reglan, phenergan, tigan, compazine, etc. None worked, although phenergan injections my husband gave me at home knocked me out and therefore stopped the vomiting, until I woke up (at least 24 hours later) and was dehydrated again. During the first two months, I lost more than 20 lbs. (I am thin to begin with) and was down to 88 lbs. I would very much like to have more children but I am afraid of hyperemisis. They talked about gastric feeding tubes and central lines but I resisted before. Are there any new treatments available? I've heard a little about Zofran and prednisone.

(2) Here are my thoughts regarding "mehs" message about hyperemisis, depression, and reglan. I had hyperemisis with my first child. It was completely debilitating. I took reglan at first also and suffered from severe depression. Later, after I had moved on to other drugs I read the manufacturer's insert that one of reglan's side effects is depression. I also have read a couple of other messages on other web sites from women who experienced severe depression with reglan as well. Most likely it exacerbated the depression I already felt from being so sick and unable to participate in major life activities such as eating, drinking, walking, reading, socializing, working, etc. I think drs. should be careful when prescribing antiemetic (sp?)drugs to treat hyperemisis so as not to exacerbate depression, if possible.

Thanks.



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