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Re: Methotrexate/Birth DefectsFrom: M. Kelly Shanahan, MD, FACOG (anonymous@obgyn.net)Sun, 10 Feb 2002 22:24:43 -0600 (CST)
At Sat, 9 Feb 2002, Liz wrote: > >My husband and I have been trying to conceive for about 5 years without >much luck (primarily due to tubal problems). We were about to begin >preparations for IVF last November, but I unexpectedly got pregnant. It >turned about to be a tubal pregnancy and was terminated in January with >Methotrexate. I don't know what we were thinking, perhaps that it was a >fluke, because we were not prepared for the discovery that I am pregnant >once again in February. It appears to be a normal, uterine pregancy. >However, I am very concerned that I took methotrexate about 30 days >before becoming pregnant. I have no idea when I ovulated, but I >apparently became pregnant at the first ovulatory cycle post >methotrexate. I have also been off my folic acid because it interferes >with the methotrexate and was not expecting to become pregnant. I would >like to know the specific risks we would be accepting if we do not >terminate this pregancy. Exactly how high is the risk of birth defects >(and what birth defects) under these circumstances? Thank you. (P.S. I >know that you cannot tell me what will happen to me and my child >exactly; I just need to know the statistics if possible before making >any final decisions.) teh risk of birth defects with one dose of methotrexate to treat an ectopic pregnancy a month ago is very, very low
-- M. Kelly Shanahan, MD, FACOG S. Lake Tahoe, CA
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